Mechanical Ventilation on Hippocampus
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorBeijing Sanbo Brain Hospital
About this trial
Ventilator-associated brain injury (VABI) frequently occurs in ICU patients. Although animal studies indicate the hippocampus as a key target of VABI, its relevance in human patients remains uncertain. In this study, the investigators aim to monitor hippocampal EEG activity during the weaning process of patients off mechanical ventilation, and also exploring the coupling between breathing patterns and hippocampal activity.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age: ≥ 18 years
ASA: I - II
w/ electrode inside hippocampus (≥ 1 contacts)
Singed consent form
Disqualifiers
Seizure occurrence ≤ 36 hours before op.
Structural brain damage
History of using: opioids, enzyme-inducing medications, sleep aids, or excessive alcohol consumption
History of mechanical ventilation (>24h)
Trial population
Patients with drug-resistant epilepsy and scheduled for sterero-electroencephalograophy (sEEG) exploration as part of pre-surgical assessment will be screened for eligibility.
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
Mechanical ventilation
Procedure/SurgeryAfter replacing the electrode, we'll monitor the EEG activity of the hippocampus and other cortex regions while weaning off mechanical ventilation.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
intracranial EEG (iEEG) recording of the hippocampus
The iEEG data from each patient will be analyzed using Python (version 3.12.4). The data will be represented as power spectral density, also known as the power spectrum or spectrum, which measures the frequency distribution of energy or power within a signal. The power spectrum for each channel will be computed using the Fast Fourier Transform (FFT).
Time frame
During the process of weaning off mechanical ventilation, assessed up to 3 hours.Sponsors and contacts
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Source ClinicalTrials.gov