Health TrialsbyHealthPanel

Mechanisms Of Disease Progression in Aortic Stenosis - the MODAS Study

ConditionsAortic StenosisImagingPathogenesisDisease ProgressionAortic Valve CalcificationGenetics
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorHeinrich-Heine University, Duesseldorf

About this trial

Biomarkers and mechanisms in the progression of aortic valve stenosis are sometimes not sufficiently understood. The current project will take into account image morphological and immunological aspects that predict the development of hemodynamically relevant aortic valve stenosis in order to identify high-risk patients and to develop further therapeutic options.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

The patient has an acquired (tricuspid) moderate aortic valve stenosis, which is the reason for regular outpatient cardiological care.

The subject has been informed verbally and in writing about the study and has given written consent to participate in this study.

Age > 18 years

Disqualifiers

The subject has contraindications for the performance of a magnetic resonance imaging or computed tomography (e.g., severe arrhythmias , contrast agent intolerance, a pacemaker, or severe renal insufficiency or severe renal insufficiency or claustrophobia).

Presence of only mild or already high-grade acquired tricuspid Aortic valve stenosis

Patient with bicuspid aortic valve

Inability to follow the instructions of study personnel

Trial population

Patients with a moderate aortic valve stenosis

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

progress of aortic stenosis

Prevalence (number of participants) measured by transthoracic echocardiography

Time frame
5 years

Secondary outcomes

1

hospitalization

Rate of patients (%) being hospitalized due to a progress of aortic stenois

Time frame
5 years
2

death

Time frame
5 years
3

occurence of myocardial infarction

Time frame
5 years
4

occurence of stroke

Time frame
5 years

Other outcomes

Sponsors and contacts

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Heinrich-Heine University, Duesseldorf

Lead sponsor

German Research Foundation

Collaborator

University of Bonn

Collaborator

University Cologne

Collaborator

Collaborative Research Center

Collaborator

Source ClinicalTrials.gov
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