Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)

ConditionsEndometriosis Endometrioma

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexFemale

Age18-45

SponsorJohns Hopkins University

About this trial

The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Subject must be a healthy woman between the ages of 18 and 45 years.

Women with diagnosed endometriosis or infertility (cases).

Women without a diagnosis of endometriosis or infertility (controls).

Subject must have regular menstrual cycles.

Disqualifiers

Pregnant women.

Study subjects with endometrial cancer.

Study subjects with a history of endometrial ablation.

Study subjects with undiagnosed uterine bleeding.

Trial population

Women between the ages of 18-45 with or without endometriosis.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

140 Participants

are grouped into 2 trial groups

Group A: Women between the ages of 18 and 45 years with or without endometriosis

Group B: Women between the ages of 18 and 45 years with or without endometrial cavity fluid undergoing IVF

Trial outcomes

Primary outcomes

Expression levels of selected ion channels in human endometrium biopsies across the menstrual cycle.

Immunolocalization of ion channel levels ENaCα, SLC5A1 and SLC5A3 in endometrial tissues.

Time frame

5 years

Secondary outcomes

Compare relative protein expression of ENaCα, SLC5A1 and SLC5A3 by immunohistochemistry

Compare relative protein expression of ENaCα, SLC5A1 and SLC5A3 by immunohistochemistry in the human endometrial biopsies from women with or without endometriosis.

Time frame

5 years

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Johns Hopkins University

Lead sponsor

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborator

National Institutes of Health (NIH)