Metabolic Profile of Bone in Professional Athletes
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorI.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
About this trial
Physical activity is a key stimulus for bone metabolism through both direct mechanisms (e.g., as a result of the applied load and/or impact) and indirect mechanisms (e.g., the activation of several metabolic pathways and the production of several mediators and effectors that have systemic effects). However, different kinds of physical activity exert different effects on bone and endocrine system.
Aim of the study is to investigate the effects of different kinds of physical activity on bone metabolism and on the relationships existing between bone metabolism, energy metabolism, hormone profile, and organ functionality.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
>/= 18 yo
healthy status
caucasians
Disqualifiers
< 18 yo
pregnancy status
ongoing or previous (<5 years) neoplasia
acute or chronic inflammatory pathologies
Trial population
A total of 200 subjects will be recruited. They will be recruited among professional athletes and technical staff of the cooperating teams
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
blood and saliva tests
Other interventionBlood and saliva will be tested for: bone turnover markers, cytokines, chemokines, adipokines, myokines and hormones regulating bone and energy metabolism
Treatment groups
200 Participants
are divided into 1 treatment groupGroup A: 11 intervention
Trial outcomes
Primary outcomes
1
Bone turnover markers
different markers of bone turnover (osteocalcin, N-terminal type I pro-collagen, beta-crosslaps, osteopontin, bone-alkaline phosphatase, tartrate-resistant acid phosphatase 5b) will be tested depending on the group of subjects considered time-by-time
Time frame
0-36 MonthsSecondary outcomes
1
myokines, adipokines, cytokines, chemokines, hormones regulating bone and energy metabolism
different markers will be assayed depending on the group of subjects
Time frame
0-36 MonthsSponsors and contacts
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Source ClinicalTrials.gov