Health Trials

Micro-osteoperforation Versus Photobiomodulation Therapy for Accelerating Maxillary Canine Retraction

ConditionsMalocclusionOrthodontic Tooth MovementMaxillary Canine Retraction
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorKufa University

About this trial

Orthodontic treatment often requires moving the upper canine teeth (the pointed teeth) into the spaces left after removing premolar teeth. This process is usually slow and can take many months, making the total treatment time longer.This study will compare two techniques that may speed up this tooth movement:

Micro-osteoperforation (MOP): A minimally invasive procedure in which a small device is used to create tiny holes in the jawbone near the canine tooth under local anesthesia. These micro-perforations stimulate the bone to remodel faster, which allows the tooth to move more quickly.

Photobiomodulation therapy (PBMT) / Low-Level Laser Therapy (LLLT): A painless, non-invasive technique that uses a low-power laser light applied to the gum tissue near the canine tooth. The laser energy stimulates cells in the bone and supporting tissues to accelerate tooth movement without any cutting or drilling.

This trial will randomly assign eligible patients into one of three groups: MOP, LLLT, or a control group receiving standard orthodontic treatment only. Each group will contain 25 participants (75 total). The main goal is to measure and compare how fast the upper canine tooth moves in each group over the first month and until the space is fully closed. The study will also measure the effect of age and sex on the results. The findings will help orthodontists choose the best, fastest, and most comfortable method for each patient to shorten overall treatment time

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age 18 to 40 years at the time of enrollment

Systemically healthy with no chronic medical conditions affecting bone metabolism or wound healing

Requiring bilateral maxillary first premolar extraction as part of a comprehensive fixed orthodontic treatment plan

Class I or mild Class II malocclusion requiring maximum anchorage canine retraction

Disqualifiers

Systemic diseases affecting bone metabolism including osteoporosis, osteopenia, diabetes mellitus, thyroid disorders, or autoimmune conditions

Current use of medications affecting bone remodeling including corticosteroids, bisphosphonates, non-steroidal anti-inflammatory drugs (NSAIDs), or vitamin D supplements

Current or recent smokers (within the past 6 months)

Pregnant or breastfeeding women

Trial design

Design model

Parallel

Treatments tested in this trial

  • Micro-osteoperforation (MOP)

    Procedure/Surgery

    Six micro-osteoperforations of 3 mm depth are created under local anesthesia (2% lidocaine with 1:100,000 epinephrine) using a PROPEL device or equivalent, with 3 perforations placed mesial and 3 distal to each maxillary canine on the buccal attached gingiva. The procedure is performed at baseline and repeated every 4 weeks until complete extraction space closure. All participants also receive standardized canine retraction using 150 g elastomeric power chain force on 0.019×0.025-inch stainless steel archwires

  • Photobiomodulation Therapy using 976 nm Diode Laser

    Device

    A 976 nm diode laser (Woodpecker LX16 Plus or equivalent) is applied in continuous-wave mode at a power of 0.13 W and energy density of 8 J/cm² per point. Irradiation is delivered at 6 mucosal sites per canine (3 buccal, 3 palatal) with the laser tip held perpendicular to the tissue surface at each point. Sessions are performed on days 0, 3, 7, and 14 after each activation, then every 2 weeks until complete extraction space closure. No anesthesia is required. All participants also receive standardized canine retraction using 150 g elastomeric power chain force on 0.019×0.025-inch stainless steel archwires

  • Conventional orthodontic canine retraction

    Other intervention

    Standard bilateral maxillary canine retraction is performed using a standardized elastomeric power chain force of 150 g on 0.019×0.025-inch stainless steel archwires. Force is recalibrated at each monthly appointment. No adjunctive biological or physical intervention is applied. This arm serves as the active comparator to quantify the absolute acceleration produced by MOP and LLLT relative to conventional mechanics alone.

Treatment groups

75 Participants
are divided into 3 treatment groups
Group A: Micro-Osteoperforation (MOP)Experimental treatment 1 intervention
Group B: Photobiomodulation Therapy / LLLT (976 nm)Experimental treatment 1 intervention
Group C: Control (Conventional Orthodontic Retraction)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Rate of maxillary canine retraction

The amount of maxillary canine distal movement (mm) measured from the CUSP TIP of the canine to the distal contact point of the lateral incisor using a digital Vernier caliper with 0.01 mm precision. Measurements are performed by a single blinded examiner at baseline and one month after initiation of canine retraction.

Time frame
12 months

Secondary outcomes

1

Total space-closure duration

ription: The total time in months from the start of canine retraction until complete closure of the extraction space, confirmed clinically by the blinded examiner.

Time frame
12 months
2

Influence of sex on rate of canine retraction

Independent-samples t-test comparison between male and female participants for two outcome measures: (1) the amount of canine distal movement (mm) at one month, and (2) the total space-closure duration (months). This analysis determines whether biological sex significantly modifies the response to micro-osteoperforation or photobiomodulation therapy during orthodontic canine retraction.

Time frame
12 months
3

Maxillary canine distal movement

Distance of canine movement measured in millimeters from study models/digital scans.

Time frame
12 months
4

Space closure duration

Time required to achieve complete extraction space closure measured in months.

Time frame
12 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Kufa University

Lead sponsor

Source ClinicalTrials.gov

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