Microplastics in the Human Respiratory System
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorWielkopolskie Centrum Pulmonologii i Torakochirurgii
About this trial
Environmental pollution from plastics has become a significant global issue, with microplastics-tiny particles resulting from plastic degradation-being increasingly detected in various environments, including aquatic ecosystems, soil, and air. These particles can enter the human body through ingestion or inhalation. Despite growing concerns, little is known about the prevalence and types of microplastics in human lungs. Some studies suggest that microplastics may negatively impact respiratory function and lead to lung diseases. Hypothetically, they could cause inflammation, metabolic disorders, and contribute to lung cancer development. However, research is still in its early stages, and conclusive evidence about the mechanisms linking microplastics to negative health effects is lacking. This study aims to quantify and characterize microplastics in the lung parenchyma and lymph nodes of patients with lung cancer and other respiratory diseases. Tissue samples will be collected during surgeries, and microplastic particles will be detected using FTIR microspectroscopy. The research may contribute to a better understanding of the role of microplastics in the development of respiratory diseases.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
patients undergoing surgery for lung cancer, emphysema, interstitial lung diseases, or other respiratory conditions,
patients undergoing lung transplantation (lungs removed from transplant recipients),
age 18 years or older,
ability to provide informed consent.
Disqualifiers
patients with a history of recent or ongoing chemotherapy, immunotherapy, or radiation therapy,
inability or unwillingness to provide informed consent,
previous lung surgeries,
insufficient tissue or blood samples available for analysis due to technical or procedural reasons.
Trial population
The study group comprises patients from the Department of Thoracic Surgery at Poznan University of Medical Sciences, Wielkopolskie Centrum Pulmonologii i Torakochirurgii. Participants include individuals undergoing surgery for lung cancer, other respiratory diseases such as emphysema and interstitial lung diseases, and lung transplantation (lungs removed from transplant recipients). The group includes individuals with diverse backgrounds, varying occupational exposure histories, smoking status (active and passive), e-cigarette use, and different comorbid conditions.
Trial design
Design model
Case-only
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Number of lung microplastics.
Number of microplastics particles detected per sample of lung tissue or regional lymph nodes obtained from patients during surgery.
Time frame
Time of surgery (Single time point; microplastic measurement is performed on a lung sample taken during surgery).Secondary outcomes
1
Types of lung microplastics.
Types of microplastics particles detected per sample of lung tissue or regional lymph nodes obtained from patients during surgery.
Time frame
Time of surgery (Single time point; microplastic measurement is performed on a lung sample taken during surgery).Sponsors and contacts
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Source ClinicalTrials.gov
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