Mixed Local for Sciatic Block

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

About this trial

Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration. On the other hand, long acting local anesthetics while provides long duration suffered from long onset time. The ideal local anesthetics should provide faster nerve block onset while providing reasonable duration to provide sustained postoperative analgesia. Mixing short and long acting local anesthetics for nerve blocks may appear to be the solution however previous published studies have demonstrated similar onset time to long acting local anesthetics and with reduced duration. Recently, the London Health Sciences Centre established an ambulatory surgical centre. Fast onset peripheral nerve block is desirable. Previous studies have not looked at popliteal sciatic block and anecdotally we feel addition of short acting local anesthetics appear to speed up onset. We are therefore interested in conducting a randomize trial to determine whether mixing short and long acting local anesthetics can speed up onset of surgical quality block.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patients (≥18 years old)

Scheduled for elective below-knee surgeries such as ankle arthroscopy, lower limb fracture fixation, toe surgeries, etc

Capable of providing informed consent

Disqualifiers

History of allergic reaction to local anesthetics

Pre-existing neurological disorders affecting lower limbs

Significant renal or hepatic impairment

Pregnancy or breastfeeding

Trial design

Design model

Parallel

Treatments tested in this trial

  • Ropivacaine and Lidocaine

    Drug

    Popliteal sciatic block using Ropivacaine 100 mg and Lidocaine 100 mg in 20 mL

  • Ropivacaine 0,5%

    Drug

    Popliteal sciatic block using ropivacaine 0.5% 20 mL

Treatment groups

110 Participants
are divided into 2 treatment groups
Group A: RopivacaineActive comparator 1 intervention
Group B: Ropivacaine anmd LidocaineExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Time to complete sensory block

The primary outcome is onset time for achievement of complete sensory block of the sciatic nerve determined via pinch test.

Time frame
Tested every 2 min up to 60 min

Secondary outcomes

1

Duration of analgesia

Patient self reported time to onset of pain or analgesics

Time frame
up to 48 hours after discharge
2

Pain score at 6 hour post-block

Numeric rating scale of patient self-reported pain at 6 hour after block placement

Time frame
6 hours after nerve block
3

Patient satisfaction

5 point categorical

Time frame
at 48 hour

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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