About this trial
Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration. On the other hand, long acting local anesthetics while provides long duration suffered from long onset time. The ideal local anesthetics should provide faster nerve block onset while providing reasonable duration to provide sustained postoperative analgesia. Mixing short and long acting local anesthetics for nerve blocks may appear to be the solution however previous published studies have demonstrated similar onset time to long acting local anesthetics and with reduced duration. Recently, the London Health Sciences Centre established an ambulatory surgical centre. Fast onset peripheral nerve block is desirable. Previous studies have not looked at popliteal sciatic block and anecdotally we feel addition of short acting local anesthetics appear to speed up onset. We are therefore interested in conducting a randomize trial to determine whether mixing short and long acting local anesthetics can speed up onset of surgical quality block.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients (≥18 years old)
Scheduled for elective below-knee surgeries such as ankle arthroscopy, lower limb fracture fixation, toe surgeries, etc
Capable of providing informed consent
Disqualifiers
History of allergic reaction to local anesthetics
Pre-existing neurological disorders affecting lower limbs
Significant renal or hepatic impairment
Pregnancy or breastfeeding
Trial design
Parallel
Treatments tested in this trial
Ropivacaine and Lidocaine
DrugPopliteal sciatic block using Ropivacaine 100 mg and Lidocaine 100 mg in 20 mL
Ropivacaine 0,5%
DrugPopliteal sciatic block using ropivacaine 0.5% 20 mL
Treatment groups
Trial outcomes
Primary outcomes
Time to complete sensory block
The primary outcome is onset time for achievement of complete sensory block of the sciatic nerve determined via pinch test.
Secondary outcomes
Duration of analgesia
Patient self reported time to onset of pain or analgesics
Pain score at 6 hour post-block
Numeric rating scale of patient self-reported pain at 6 hour after block placement
Patient satisfaction
5 point categorical
Locations
Sponsors and contacts
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