The main goal of this project is to study the mechanisms of epileptic activities using intracranial macro and micro electrodes in epileptic patients undergoing pre-surgical investigation.
The recordings will also be used to study physiological mechanisms like sleep and different cognitive functions.
Patients with focal drug-resistant epilepsy
Patients who undergo a presurgical evaluation with intracranial electrodes in the videoEEG unit of the Neurology department at the Pitié-Salpêtrière hospital.
Patients who have been informed and provided written informed consent to take part in the study
Contraindication for an intracranial investigation (with macro-electrodes) : intercurrent infectious syndrome, decompensated associated pathology (cardiac, pulmonary, renal, hepatic), patient with increased risk of infection (ex: under immunosuppressive therapy)
Pregnant or parturient woman
Breastfeeding woman
Minor person or legally protected adult (tutelage, legal guardianship, maintenance of justice)
Single group
Intracranial macro-microelectrode recording
DeviceAdditionnally to clinical macroelectrodes, Benkhe-Fried depth macro-microelectrodes will be implanted and recorded during the pre-surgical investigation of epileptic patients
Identification of single unit changes at seizure emergence
In order to identify biomarkers of epileptic seizures we will study single neuron activities (firing rate) using spike sorting at different time periods (before, during and after seizures and during interictal periods) We expect to observe significant changes in firing rate across the different time periods.
Identification of local field potential (LFP) changes at seizure emergence
In order to identify biomarkers of epileptic seizures we will study LFP power using time frequency analysis at different time periods (before, during and after seizures and during interictal periods) We expect to observe significant changes in LFP power across the different time periods.
Comparison of single unit activity before seizure according to brain localization
We will compare firing rate before seizure according to brain regions (anatomy and involvement in the seizure onset zone)
Identification of single unit changes during physiological brain activity
We will compare firing rates during resting states and stimulus induced states. We expect to observe significant changes in firing rate between states.
Identification of LFP power changes during physiological brain activity
We will compare LFP power during resting states and stimulus induced states. We expect to observe significant changes in LFP power between states.
Multilevel study of brain activity
We will look for correlation between firing rates and LFP power changes.
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