Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease

Change in daily walking duration during activities of daily living from baseline to 12 months as measured by the PAMSys pendant

Daily walking duration (hours) will be measured by the PAMSys pendant. PAMSys is a FDA-listed Class II wearable device for measuring physical activity and posture during activities of daily living. PAMSys will be worn for 1 week after the baseline, 3 month, 6 month, 9 month, and 12 month visits.

Change in daily number of sit to stand transitions (count) during activities of daily living from baseline to 12 months as measured by the PAMSys pendant.

Daily number of sit to stand transitions will be measured by the PAMSys pendant. PAMSys is a FDA-listed Class II wearable device for measuring physical activity and posture during activities of daily living. PAMSys will be worn for 1 week after the baseline, 3 month, 6 month, 9 month, and 12 month visits.

Change in scores of Unified Huntington's Disease Rating Scale (UHDRS) from baseline to 12 months

A clinical tool used to assess motor, cognitive, and behavioral symptoms in individuals with Huntington's disease (HD). There are 5 parts to UHDRS 1. Total Motor Score: Scores range from 0 to 124. Higher scores represent a worse outcome. 2. Total Functional Capacity: Scores range from 0 to 13. Lower scores represent a worse outcome. 3. Behavioral Assessment: Scores range from 0 to 88. Higher scores represent a worse outcome. 4. Cognitive Assessments: Inclues Stroop test, Verbal Fluency, and Symbol Digit Modalities Test. Lower scores represent a worse outcome.

Change in intelligibility when reading a standard Rainbow passage from baseline to 12 months as measured by BioDigit Speech

Speech data will be collected from participants while reading a standard Rainbow passage on a monthly basis for 12 months. BioDigit Speech, and automatic speech analysis software, will be used to analyze the collected speech data to calculate intelligibility of speech during reading a standard Rainbow passage.

Change in walking speed during activities of daily living from baseline to 12 months as measured by the PAMSys Ankle sensor

median, 90 percentile and 96 percentile stride velocity (m/s) will be measured by the PAMSys Ankle sensor. PAMSys Ankle sensor will be worn for 1 week after the baseline, 3 month, 6 month, 9 month, and 12 month visits.

Change in cadence during activities of daily living from baseline to 12 months as measured by the PAMSys pendant

Median, 90 percentile and 96 percentile cadence (steps/min) will be measured by the PAMSys pendant. PAMSys pendant will be worn for 1 week after the baseline, 3 month, 6 month, 9 month, and 12 month visits.

Change in tapping rate (number of taps per minute) from baseline to 12 months as measured by the BioDigit Clinic and BioDigit Home tablets

Finger tapping test will be collected from participants on a monthly basis for 12 months.

Change in daily number of hand goal-directed movements during activities of daily living from baseline to 12 months as measured by the PAMSys ULM wrist sensor

PAMSys ULM wrist sensor measures goal directed movements of the hand during activities of daily living. PAMSys ULM wrist sensors will be worn for 1 week after the baseline, 3 month, 6 month, 9 month, and 12 month visits.

Change in the Verbal Fluency test score

Verbal fluency test data will be collected at baseline, 3 month, 6 month, 9 month and 12 month visits.