The goal of this observational study is to investigate the multi-omics characterization early-stage lung cancer exhibiting distinct phenotypes including lung cancer associated with cystic airspaces, multiple primary lung cancers, and so on. The main questions it aims to answer are:
* What are the differences in pathogenesis of non-small cell lung cancer with different phenotypes explored by multi-omics? * Whether differential genes lead to potential prognostic models and therapeutic targets? Participants will be followed up after surgery to answer prognosis: whether they have recurred, and the time to recurrence.
Male or female patients:18-75 years old;
ECOG score:0-1;
Histopathologically confirmed TNM stage I-II NSCLC;
Considered multiple or solitary primary lung cancer by clinical criteria (Martini-Melamed criteria and ACCP criteria);
A history of previous or co-existing malignant tumors;
Systemic anti-tumor therapies, including chemotherapy, radiotherapy, or targeted therapies (such as monoclonal antibodies, small-molecule tyrosine kinase inhibitors, among others), were administered prior to enrollment;
Refusal to participate in the study.
Male or female patients:18-75 years old;
Patients with non-small cell lung cancer with indication for surgery.
Cohort
Prospective
Not listed
Immune repertoire sequencing
DNA methylome sequencing
RNA sequencing
Genomic sequencing
Metabolomics analysis
Radiomics analysis
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Central South University
Lead sponsor
Second Xiangya Hospital of Central South University
Sponsor institution
