Multilevel Exercise Response in Rowers
ConditionHealthy Adult Participants
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age19-24
SponsorPoznan University of Physical Education
About this trial
This observational study aims to evaluate multilevel physiological, molecular, metabolic, intestinal, immunological, and psychophysiological responses to rowing-specific exercise in elite rowers. The study is designed to investigate how maximal and prolonged rowing ergometer exercise influences integrated adaptive mechanisms related to mitochondrial function, metabolic regulation, intestinal permeability, immune activation, DNA damage response, and psychological status.
Thirty members of the Polish Youth National Rowing Team, aged 19-24 years, will participate in the study during two different training periods. During the competitive phase, participants will perform a 2000-m maximal rowing ergometer test, whereas during the preparatory phase they will complete a 6000-m rowing ergometer test. Blood samples and physiological measurements will be collected before exercise, immediately after exercise, and after 1 hour of recovery.
The study will assess gene expression, circulating biomarkers, flow cytometry parameters, blood morphology, lactate concentration, continuous glucose monitoring data, wearable metabolic sensor measurements, nutritional status, and psychological responses. The primary objective is to identify integrated biomarkers reflecting exercise load, recovery dynamics, and adaptive capacity in highly trained athletes. The study also aims to improve understanding of the interaction between metabolic, mitochondrial, intestinal, immunological, and psychophysiological responses to intensive exercise in rowing.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Male and female members of the Polish Youth National Rowing Team.
Age between 19 and 24 years.
Regular participation in structured rowing training.
Medical clearance for participation in maximal exercise testing.
Disqualifiers
Lack of consent for blood sampling or study participation.
Current injury or health condition contraindicating maximal exercise.
Acute infection, fever, or inflammatory condition at the time of testing.
Use of anti-inflammatory medications.
Trial population
The study population will consist of male and female competitive rowers aged 19-24 years who are members of the Polish Youth National Rowing Team. Participants will be recruited from athletes engaged in regular high-performance rowing training and who participate in standardized rowing ergometer testing as part of routine performance monitoring across different phases of the training season. All participants will be medically cleared for maximal exercise testing and will represent elite-level endurance athletes.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
2000-m rowing ergometer test
Other interventionA standardized maximal rowing ergometer exercise test performed over a distance of 2000 meters during the competitive phase of the training season to evaluate acute physiological and molecular responses to high-intensity exercise.
6000-m rowing ergometer test
Other interventionA standardized prolonged rowing ergometer exercise test performed over a distance of 6000 meters during the preparatory phase of the training season to evaluate physiological and molecular responses to prolonged submaximal exercise.
Treatment groups
30 Participants
are divided into 2 treatment groupsGroup A: Elite male rowers2 interventions
Group B: Elite female rowers2 interventions
Trial outcomes
Primary outcomes
1
Changes from baseline in PPARGC1A (PGC-1α) gene expression
Marker of mitochondrial biogenesis and metabolic adaptation to exercise.
Time frame
At rest (before the exercise test), immediately after the end of the test, and after 1 hour of recovery.2
Changes from baseline in TFAM gene expression.
Marker of mitochondrial DNA maintenance and transcription.
Time frame
At rest (before the exercise test), immediately after the end of the test, and after 1 hour of recovery.3
Changes from baseline in PRKAA1 (AMPKα1) gene expression.
Marker of cellular energy sensing and metabolic stress response
Time frame
At rest (before the exercise test), immediately after the end of the test, and after 1 hour of recovery.4
Changes from baseline in SOD2 gene expression.
Marker of mitochondrial antioxidant defense.
Time frame
At rest (before the exercise test), immediately after the end of the test, and after 1 hour of recovery.Secondary outcomes
1
Changes from baseline in blood lactate concentration.
Marker of exercise intensity and metabolic stress.
Time frame
At rest (before the exercise test), immediately after the end of the test, after 1 hour of recovery.2
Changes from baseline in hemoglobin concentration
Assessment of exercise-induced changes in hemoglobin concentration.
Time frame
At rest (before the exercise test), immediately after the end of the test, after 1 hour of recovery.3
Changes from baseline in hematocrit value
Assessment of exercise-induced changes in hematocrit value.
Time frame
At rest (before the exercise test), immediately after the end of the test, after 1 hour of recovery.4
Changes from baseline in red blood cell count
Assessment of exercise-induced changes in red blood cell count.
Time frame
At rest (before the exercise test), immediately after the end of the test, after 1 hour of recovery.Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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