Multimodal Opioid-Free Anesthesia in RIRS

ConditionsKidney Stone Retrograde Intrarenal Surgery (RIRS)Postoperative Pain

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-65

Sponsormurat sahin

About this trial

The goal of this clinical trial is to evaluate whether a dexmedetomidine-ketamine based opioid-free anesthesia (OFA) protocol can provide effective analgesia compared to conventional fentanyl-based anesthesia in adult patients undergoing elective retrograde intrarenal surgery (RIRS). The main questions it aims to answer are:

Does opioid-free anesthesia reduce postoperative opioid consumption compared to fentanyl-based anesthesia? Does opioid-free anesthesia result in lower postoperative pain scores?

Researchers will compare the dexmedetomidine-ketamine group to the fentanyl-based anesthesia group to see if opioid-free anesthesia reduces opioid requirements and improves recovery quality.

Participants will receive either a dexmedetomidine-ketamine based OFA protocol or conventional fentanyl-based anesthesia during surgery and will be monitored for pain, opioid consumption, and recovery outcomes postoperatively.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

Dexmedetomidine-Ketamine Opioid-Free Anesthesia
Drug
Opioid-free anesthesia protocol using dexmedetomidine infusion and ketamine administration without intraoperative opioid use.
Fentanyl-Based Anesthesia
Drug
Conventional opioid-based anesthesia protocol using fentanyl during surgery.

Treatment groups

60 Participants

are divided into 2 treatment groups

Group A: Opioid-Free Anesthesia GroupExperimental treatment 1 intervention

Group B: Opioid-Based Anesthesia GroupActive comparator 1 intervention

Trial outcomes

Primary outcomes

Postoperative Pain Intensity

Postoperative pain intensity assessed using the Numeric Rating Scale (NRS, 0-10) at PACU arrival, 30 minutes, and 60 minutes postoperatively.

Time frame

Within 60 minutes postoperatively

Secondary outcomes

Postoperative Opioid Consumption

Total postoperative tramadol consumption during the early postoperative recovery period.

Time frame

Within 60 minutes postoperatively

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

murat sahin

Lead sponsor

Sisli Hamidiye Etfal Training and Research Hospital

Sponsor institution

Source ClinicalTrials.gov

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