Mystical Experiences Without Psychedelics and How Integration Improves Well-Being in Adults

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorBaylor University

About this trial

The goal of this clinical trial is to evaluate whether a guided, non-drug spiritual intervention can facilitate mystical-type experiences and improve well-being in Christian adults.

The main questions it aims to answer are:

* Does the guided spiritual intervention produce measurable mystical experiences? * Does participation in the intervention and assigned integration program lead to improvements in well-being over time?

Researchers will compare a Christian-based integration program to a structured control integration program to determine whether Christian-based integration leads to greater improvements in well-being.

Participants will:

* Complete baseline questionnaires assessing spiritual experiences, religiosity, and well-being * Complete one in-person session of the "guided invocation for mystical experience" * Be randomly assigned to complete either a Christian-based or control integration program for 4 weeks * Complete follow-up assessments at 1 month and 2 months

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

age 18 years or older;

active Christian faith;

willing to experience hypnosis;

English-speaking; able to complete one in-person session and 1- and 2-month follow-up assessments.

Disqualifiers

prior psychedelic use;

severe mental illness (e.g., schizophrenia, bipolar disorder, psychosis, borderline personality disorder);

unwillingness to experience hypnosis;

inability to complete study procedures

Trial design

Design model

Parallel

Treatments tested in this trial

  • Guided Invocation for Mystical Experience

    Behavioral

    Participants will complete a single, in-person Guided Invocation for Mystical Experience (GIME) session conducted by a trained practitioner using a standardized protocol. The session includes an initial briefing and rapport-building period, followed by a structured breathing exercise (approximately 8 minutes) designed to facilitate a non-ordinary state of consciousness. Participants then receive guided imagery and verbal suggestions intended to promote relaxation, absorption, and experiential openness. The practitioner delivers a standardized script targeting features commonly associated with mystical-type experiences (e.g., unity, positive affect, and altered perception of time and space). The session includes a brief period of silent introspection, followed by re-alerting procedures. The total session duration is approximately 60 minutes.

Treatment groups

120 Participants
are divided into 2 treatment groups
Group A: Structured Christian IntegrationExperimental treatment 1 intervention
Group B: Structured Control IntegrationActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Frequency of a Complete Mystical Experience as Assessed by the Mystical Experience Questionnaire

Frequency of complete mystical experiences will be assessed using the 30-item Mystical Experience Questionnaire (MEQ30), a validated self-report measure designed to assess key phenomenological features of mystical-type experiences. The MEQ30 includes four empirically derived subscales: Mystical, Positive Mood, Transcendence of Time and Space, and Ineffability. Participants rate the extent to which each item describes their experience. Higher scores reflect greater endorsement of mystical-type features. To determine whether a participant had a complete mystical experience, scores will be calculated for each of the four subscales and expressed as a percentage of the maximum possible score for that subscale. A complete mystical experience is defined as meeting or exceeding 60% of the maximum possible score on all four MEQ30 subscales. The frequency of complete mystical experiences will then be calculated as the proportion of participants who meet this criteria.

Time frame
Immediately following the in-person guided invocation for mystical experience session
2

PERMA Well-Being Scale

The PERMA Well-Being Scale measures five dimensions of well-being-Positive Emotion, Engagement, Relationships, Meaning, and Accomplishment-based on Martin Seligman's PERMA model. The scale contains 23 items, with 3-5 items per subdomain, scored on a Likert scale. Butler and Kern (2016) established the scale's internal consistency (α \> .80) and construct validity.

Time frame
Baseline, 1 month, and 2 months post-intervention
3

Ryff Psychological Wellbeing Scale

The Ryff Psychological Wellbeing Scale (PWB) assesses six domains of well-being: autonomy, environmental mastery, personal growth, positive relationships, purpose in life, and self-acceptance. It includes 42 items, scored on a Likert scale, with shorter versions available. Psychometric evaluation revealed high internal consistency (α \> .80) and test-retest reliability across diverse populations (Ryff \& Keyes, 1995). Example items include, "I like most parts of my personality" (self-acceptance) and "I am not afraid to voice my opinions, even when they are in opposition to most people" (autonomy).

Time frame
Baseline, 1 month, and 2 months post-intervention
4

Multidimensional Existential Meaning Scale

The Multidimensional Existential Meaning Scale (MEMS) measures existential meaning across three dimensions: coherence, purpose, and mattering. The scale consists of 15 items rated on a 7-point Likert scale ranging from "strongly disagree" to "strongly agree." Higher scores indicate a greater sense of existential meaning. Psychometric evaluations by George and Park (2017) demonstrated excellent internal consistency (α \> .90) and robust construct validity. Example items include, "I understand how my life fits into the larger picture," "I feel that my life has a clear sense of purpose," and "I believe that my life is significant and matters." This scale is particularly suited for studies exploring the depth and breadth of meaning in individuals' lives.

Time frame
Baseline, 1 month, and 2 months post-intervention

Secondary outcomes

1

Brief Multidimensional Measure of Religiousness/Spirituality

The Brief Multidimensional Measure of Religiousness/Spirituality (BMMRS) is a comprehensive tool designed to assess various dimensions of religious and spiritual life. The measure includes 29 items spanning multiple subdomains, such as religious practices (e.g., attendance at services, prayer), spiritual beliefs (e.g., beliefs in higher powers), coping strategies, and spiritual experiences. Items are rated on Likert scales or categorical responses, depending on the subdomain. The BMMRS has demonstrated strong psychometric properties, with internal consistency typically exceeding α = .80 across its subscales and evidence of validity in diverse cultural and religious populations.

Time frame
Baseline
2

Modified Tellegen Absorption Scale

The Modified Tellegen Absorption Scale (MODTAS) is a revised version of the original Tellegen Absorption Scale, designed to assess an individual's tendency to become fully engaged in sensory and imaginative experiences. It includes 34 items rated on a 5-point Likert scale from "not at all true" to "extremely true," improving upon the original true/false format to enhance psychometric robustness. The MODTAS measures various aspects of experiential absorption, including responsiveness to engaging stimuli, imaginative involvement, and altered states of consciousness. Jamieson (2005) reported strong internal consistency (α \> .90) and construct validity in relation to hypnotizability and imaginative suggestibility.

Time frame
Baseline
3

Qualitative Characteristics of the Experience

Thematic analysis of participant-reported experiences collected via post-session interviews.

Time frame
Immediately following the in-person guided invocation for mystical experience session.
4

Mysticism Scale

The Mysticism Scale evaluates mystical experiences, focusing on dimensions such as ineffability, transcendence of time and space, and unity. It includes 32 items, rated on a Likert scale, and has been validated in multiple cultural contexts (Hood et al., 2001). Hood (1975) reported strong psychometric properties, with internal consistency above α = .80. An example item is, "I have had an experience where everything seemed to disappear, leaving only a sense of unity."

Time frame
Immediately following the in-person guided invocation for mystical experience session

Other outcomes

1

Acceptability questions

If given the opportunity, how likely would you be to participate in this activity again? How likely are you to recommend this experience to others? Both of these questions will be answered on a 0-10 scale where 0 = not at all likely and 10 = extremely likely.

Time frame
Immediately after the in-person guided invocation for a mystical experience session
2

Self-identified spirituality

In whatever way you define it, how spiritual do you consider yourself to be? Participants will respond to this question on a 0-100 visual analog scale where 0 = not at all spiritual and 100 = extremely spiritual.

Time frame
Baseline, 1 month, and 2 months post-intervention

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Baylor University

Lead sponsor

Templeton World Charity Foundation

Collaborator

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