This study aims to compare the efficacy and safety of Melanocyte Keratinocyte Transplantation Procedure (MKTP) combined with 308-nm excimer laser versus Jodhpur technique combined with 308-nm excimer laser in the treatment of stable non-vitiligo leukoderma. Twenty-two patients with stable depigmented lesions will be enrolled. In each patient, two comparable lesions will be treated using different techniques. Clinical outcomes including percentage of repigmentation, color match, time to onset of repigmentation, complications, and histological changes will be assessed during follow-up to determine the optimal surgical treatment approach for non-vitiligo leukoderma.
Age 18 to 60 years.
Clinically diagnosed stable non-vitiligo leukoderma.
Stable lesion(s) for at least 6 months with no progression.
Inadequate response to conventional medical therapy.
Vitiligo or suspected active vitiligo.
History of keloid or hypertrophic scar formation.
Active infection at donor or recipient sites.
Bleeding disorders or anticoagulant therapy that cannot be safely discontinued.
Parallel
Melanocyte Keratinocyte Transplantation Procedure (MKTP)
Procedure/SurgeryAutologous melanocyte-keratinocyte cell suspension prepared using enzymatic separation and applied to a dermabraded recipient site.
Jodhpur Technique
Procedure/SurgeryAutologous non-cultured epidermal cell transfer technique using dermabraded donor skin particles applied directly to the recipient site without enzymatic processing
308-nm Excimer Laser
DeviceExcimer laser therapy initiated approximately 14 days after surgery, administered twice weekly for 12-16 weeks with dose adjustment according to erythema response
Mean Percentage Repigmentation of Target Lesions
Time to Onset of Repigmentation
Color Match Assessment
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