Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorNational Research Center for Rehabilitation Technical Aids
About this trial
This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and the approaches used to improve and restore cognitive function.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults being able to walk at least a block, and
Adults with subjective cognitive decline (SCD), or
Adults with mild cognitive impairment (MCI), or
Adults with normal cognitive function
Disqualifiers
Clinical diagnosis of dementia
Adults who cannot follow the protocal
Trial design
Design model
Parallel
Treatments tested in this trial
multi-modal targeted intervention (e.g., cognitive training, exercise, games)
Combination productThe Intervention group will be given recommended interventions tailored to individuals based on their risks (e.g., physical exercise programs, cognitive training, dietary advice, control of blood pressure and cholesterol, healthy diet, control obesity, stop smoking,reduce alcohol excess)
Treatment groups
100 Participants
are divided into 2 treatment groupsGroup A: ControlNo intervention 0 interventions
Group B: Cognitive trainingExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Change in Cognitive function (SCD-9)
The SCD-9 questionnaire is used to assess cognitive function of participants.
Time frame
Change from Baseline Cognitive test results at 3 months.2
Change in Cognitive function (MoCA)
The Montreal Cognitive Assessment test is used to assess cognitive function of participants.
Time frame
Change from Baseline Cognitive test results at 3 months.3
Change in Cognitive function (AD8)
The AD8 test is used to assess cognitive function of participants.
Time frame
Change from Baseline Cognitive test results at 3 months.4
Change in Cognitive function (CDR)
The Clinical Dementia Rating (CDR) test is used to assess cognitive function of participants.
Time frame
Change from Baseline Cognitive test results at 3 months.Secondary outcomes
1
Change in Physical capacity (TUG)
The timed up and go (TUG) test is used to evaluate physical capacity of participants.
Time frame
Change from Baseline physical capacity test results at 3 months.2
Change in Physical capacity (chair standing)
The 30-second chair standing test is used to evaluate physical capacity of participants.
Time frame
Change from Baseline physical capacity test results at 3 months.Other outcomes
1
Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
Number of participants with treatment-related adverse events as assessed by CTCAE v5.0.
Time frame
Up to 24 months.Sponsors and contacts
Click on the lead sponsor to view all of their trials.
National Research Center for Rehabilitation Technical Aids
Lead sponsor
Nanjing Brain Hospital
Collaborator
The Third People's Hospital of Yunnan Province
Collaborator
Central South University
Collaborator
Beijing academy of science and technology
Collaborator
Beijing University of Chinese Medicine
Collaborator
Source ClinicalTrials.gov