Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model

ConditionsSubstance Use Healthy

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-22

SponsorUniversity of Michigan

About this trial

This study seeks to understand individual differences in personality, brain function, and behavior.

Study hypothesis:

\- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

18-22 years old at baseline

Right-handed

Medically/physically able to give informed consent

English-speaking

Disqualifiers

Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)

History of psychosis in self or first-degree relative

Current treatment for substance use disorder

Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)

Trial design

Design model

Single group

Treatments tested in this trial

fMRI
Device
Participants will have an MRI to scan participants brains and will wear skin conductance electrodes on the hand and fill out questionnaires. Scanning will take approximately 90 minutes. While lying in the scanner, participants will be asked to perform some tasks. The tasks will be presented to participants visually on a screen in the scanner and eye movements will also be tracked during some of these tasks. Participants will respond to stimuli with button presses that are recorded by computer.
Questionnaires and surveys
Behavioral
Participants will have multiple visits during this study and fill out various surveys at these visits.
Behavioral tasks and eye tracking
Behavioral
Participants will perform behavioral tasks while having eye-tracking hardware monitor participants eye movements. A video camera will be used to record eye movements during the behavioral tasks.

Treatment groups

294 Participants

are divided into 1 treatment group

Group A: Assessment groupExperimental treatment 3 interventions

Trial outcomes

Primary outcomes

Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use score

PavCA bias score based on eye gaze during the Pavlovian conditioned approach task will be correlated with a cannabis use composite score based on the Substance Use History and Timeline Follow-Back.

Time frame

Baseline

Secondary outcomes

Correlation between PavCA bias score (out-of-scanner) and activation from the Cannabis Cue Reactivity Task (P-CAN)

PavCA bias score based on eye gaze during the Pavlovian conditioned approach task will be correlated with the first principal component of average parameter estimates from the following regions extracted for the cannabis vs. neutral contrast: ventral striatum, anterior cingulate, posterior cingulate, insula, amygdala, orbitofrontal cortex, inferior occipital cortex, and inferior parietal cortex

Time frame

Baseline

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Michigan

Lead sponsor

National Institute on Drug Abuse (NIDA)

Collaborator

Source ClinicalTrials.gov

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