Health TrialsbyHealthPanel

Neurofeedback to Reduce Spontaneous Recovery of Threat Expectancy

ConditionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorTrustees of Princeton University

About this trial

This study tests the efficacy of a new behavioral intervention with the goal of reducing spontaneous recovery of threat expectancy in healthy adults. This real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention delivers feedback based on a functional connection between the prefrontal cortex and the hippocampus.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adults aged 18-50

No history of psychiatric disorders or neurological disorders affecting the central nervous system.

Are not currently taking psychoactive medication or drugs of abuse.

Must be eligible to enter an MRI (i.e., no permanent metal or medical implants)

Disqualifiers

Pregnancy (female participants)

Outside of age range

History of psychiatric or neurological disease

Currently taking psychoactive medication or drugs of abuse

Trial design

Design model

Parallel

Treatments tested in this trial

  • Active Real-time fMRI Neurofeedback

    Behavioral

    Active neurofeedback to target a functional connection associated with increased memory control ability

  • Sham Real-time fMRI neurofeedback

    Behavioral

    Sham neurofeedback

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: Active NeurofeedbackExperimental treatment 1 intervention
Group B: Control NeurofeedbackSham comparator 1 intervention

Trial outcomes

Primary outcomes

1

Spontaneous recovery behavior

The investigators will assess neurofeedback related changes in behavioral threat expectancy ratings in a discriminatory Pavlovian conditioning task. Spontaneous recovery is taken as the difference in responding to the conditioned stimulus that was paired with an outcome (CS+) vs. the conditioned stimulus that was not paired with an outcome (CS-) during a test of extinction recall following acquisition and extinction learning.

Time frame
Baseline and fourth fMRI session (out of four total fMRI sessions). At most 60 days will elapse between the start of data collection for a participant and their final fMRI session.

Secondary outcomes

1

Neurofeedback learning

The investigators will assess the overall trend in neurofeedback scores over the course of the intervention. If neurofeedback learning is successful, the investigators expect participants in the experimental group to increase the number of positive neurofeedback instances as the experiment progresses.

Time frame
Second and third fMRI sessions (out of four total fMRI sessions). At most 60 days will elapse between the start of data collection for a participant and their final fMRI session.

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Trustees of Princeton University

Lead sponsor

National Institute of Mental Health (NIMH)

Collaborator

Source ClinicalTrials.gov
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