About this trial
The goal of this clinical trial is to assess differences in the fecal microbiota and metabolome associated with insufficient and sufficient sleep, and to evaluate the response and recovery of the microbiota to changes in participant sleep profiles.
Researchers will compare the effect of sleep intervention on both insufficient and sufficient sleepers to identify differences in fecal microbiota structure and function between cohorts during habitual sleep and during the sleep alteration intervention period..
Participants will be assigned to one of two cohorts based on their current sleep habits. Cohort 1 are participants who have insufficient sleep at baseline; this cohort will be assigned to spend 1.5 hours more in bed per night. Cohort 2 are participants who have sufficient sleep at baseline; this cohort will be assigned to spend 1.5 hours less in bed per night. The sleep intervention lasts for 14 days.
Eligibility criteria
Qualifiers
Men between 20 - 50 years of age and pre-menopausal women between 20 - 45 years of age (inclusive).
Consistent schedule during daytime hours.
BMI 18.5 - 35 kg/m2 (inclusive).
Good physical and mental health as established by self-reported medical history.
Disqualifiers
None
Trial design
Treatments tested in this trial
- Increase sleep by 90 minutes
- Decrease sleep by 90 minutes