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NMR Based Metabolomics Kinetics in ARDS Patients

ConditionARDS
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorSanjay Gandhi Postgraduate Institute of Medical Sciences

About this trial

Acute respiratory distress syndrome (ARDS) is a life-threatening condition requiring respiratory support to maintain oxygenation. Very few biomarkers about ARDS have been identified but none of them has a sufficient specificity or sensitivity to characterize by itself the severity of lung condition. Investigators hypothesize that there is considerable change occurring in metabolic profiles in mild, moderate, and severe ARDS in comparison to healthy cohort, which can be detectable through serum analysis using NMR based metabolomics study. This research would help to understand metabolomics kinetics during the ARDS disease progression. Overall, NMR-based metabolomics study would provide an insight into the mediators involved in pathogenesis and progression of ARDS.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Critically ill adult patients having mild ARDS with onset less than 72 hours

Disqualifiers

Age less than 18 years or more than 65 years

Expected survival <72 hours

Refusal from family member

Trial population

Patients who fulfill criteria of mild ARDS (PaO2/FiO2 200-300) will be considered for possible inclusion. For comparative analysis, age matched healthy control (from healthy blood donor volunteer will also be included in the study.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

120 Participants
are grouped into 2 trial groups
Group A: Acute Respiratory Distress Syndrome
Group B: Healthy

Trial outcomes

Primary outcomes

1

To identify the potential biomarkers in mild ARDS using NMR based metabolomics

NMR based metabolomics in the serum of patients with mild ARDS

Time frame
Up to the 72 hours after the diagnosis of mild ARDS
2

To study the kinetics of NMR based metabolomics in mild ARDS and its association with progression of ARDS severity.

Changes in NMR based metabolomics in serum of patients with mild ARDS

Time frame
Three weeks after diagnosing mild ARDS or till ICU discharge (whichever comes first)

Secondary outcomes

1

Correlation of the infection etiology and NMR based metabolomics

To study microorganism specific changes in NMR based metabolomics, if any

Time frame
Up to the three weeks after the diagnosis of mild ARDS or ICU discharge (whichever comes first)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sanjay Gandhi Postgraduate Institute of Medical Sciences

Lead sponsor

Centre of BioMedical Research, India

Collaborator

Source ClinicalTrials.gov
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