Non-Surgical Periodontal Therapy and Cardiac Biomarkers in Stable Angina
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorOndokuz Mayıs University
About this trial
The goal of this clinical study is to learn whether gum treatment can improve heart health. Researchers will compare blood markers related to heart disease before and after routine gum treatment.
The main questions this study aims to answer are:
Is gum disease a risk factor for heart disease? Can treating gum disease lower the risk of heart disease? Adults with stable angina (a type of heart disease) and adults without heart disease may take part in this study.
All participants will receive routine, non-surgical gum treatment, which is a standard dental care procedure. This includes professional cleaning to remove plaque and tartar from the teeth and practical education on tooth brushing and cleaning between the teeth. The treatment will be performed by a single researcher and completed in one visit within about one hour.
Participants will:
Provide a blood sample before gum treatment Receive routine, non-surgical gum treatment Return after three months for a follow-up visit Provide a second blood sample This study does not involve experimental drugs or devices. Participation is voluntary, and there is no cost to participants. The results may help researchers better understand how gum health is related to heart health.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Willingness to participate in the study and provide written informed consent
Age 18 years or older
No periodontal treatment within the past 6 months
No use of local or systemic antibiotics within the past 3 months
Disqualifiers
Unwillingness to participate in the study or to provide informed consent
Age under 18 years
Use of local or systemic antibiotics for the treatment of widespread infection
within the past 3 months
Trial design
Design model
Parallel
Treatments tested in this trial
Non-surgical periodontal therapy (scaling and root planing)
Procedure/SurgeryNon-surgical periodontal therapy will include full-mouth scaling and root planing performed using hand instruments and/or ultrasonic devices to remove supra- and subgingival plaque and calculus.
Non-surgical periodontal therapy (Professional dental cleaning)
Procedure/SurgerySupragingival calculus and plaque removal with standardized oral hygiene instruction.
Treatment groups
60 Participants
are divided into 3 treatment groupsGroup A: Stable angina and periodontitis group (SAP group)Experimental treatment 1 intervention
Group B: Periodontitis group (P group)Experimental treatment 1 intervention
Group C: Control group (C group)Active comparator 1 intervention
Trial outcomes
Primary outcomes
1
Change in serum ischemia-modified albumin (IMA) concentration after non-surgical periodontal therapy
Serum ischemia-modified albumin (IMA) concentration measured in nanograms per milliliter (ng/mL) using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Assessed at baseline and 3 months after non-surgical periodontal therapy.
Time frame
Baseline and 3 monthsSecondary outcomes
1
Change in serum soluble suppression of tumorigenicity 2(sST2) concentration after non-surgical periodontal therapy
Serum soluble suppression of tumorigenicity 2 (sST2) concentration measured in picograms per milliliter (pg/mL) using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Assessed at baseline and 3 months after non-surgical periodontal therapy.
Time frame
Baseline and 3 monthsSponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: