Noninvasive Real-Time Arterial Waveform Monitoring for Cardiovascular Disease Assessment
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorAnhui Provincial Cancer Hospital
About this trial
The goal of this observational study is to learn whether noninvasive real-time arterial waveform monitoring can be used to assess cardiovascular diseases in adults. The main question it aims to answer is:
Can photoacoustic imaging accurately capture arterial waveforms from patients' fingers? Can features extracted from the arterial waveforms reflect the type and severity of cardiovascular diseases? Participants will be asked to place their fingers into the imaging device, where their finger arterial pulse information will be noninvasively recorded.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 18-80 years
Able to provide informed consent
For AR group: clinically diagnosed aortic regurgitation
For AS group: clinically diagnosed aortic stenosis
Disqualifiers
History of recent cardiac surgery or intervention (<6 months)
Hand disorders affecting finger mobility (e.g., arthritis)
Pregnant or breastfeeding women
Participation in other studies affecting arterial waveform
Trial population
Participants will be recruited from adult patients attending the cardiology department at the First Affiliated Hospital of University of Science and Technology of China, including individuals diagnosed with aortic regurgitation (AR) or aortic stenosis (AS), as well as healthy adult volunteers without known cardiovascular disease. Recruitment will focus on adults aged 18-80 years who are able to comply with finger arterial waveform measurement procedures.
Trial design
Design model
Case-control
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
15 Participants
are grouped into 3 trial groupsGroup A: Healthy Subjects
Group B: Aortic Regurgitation (AR) Patients
Group C: Aortic Stenosis (AS) Patients
Trial outcomes
Primary outcomes
1
Evaluation of the state of aortic regurgitation and aortic stenosis by photoacoustic tomography
To determine the feasibility of using photoacoustic tomography to differentiate aortic regurgitation and aortic stenosis based on arterial waveform measurements.
Time frame
At enrollment (single time point)Secondary outcomes
1
Rise time of photoaocustic arterial waveform
To determine the systolic upstroke rise time of arterial waveforms using photoacoustic tomography
Time frame
At enrollment (single time point)2
Decay time of photoaocustic arterial waveform
To determine the diastolic decay time of arterial waveforms using photoacoustic tomography
Time frame
At enrollment (single time point)3
Dicrotic notch time of photoaocustic arterial waveform
To determine the dicrotic notch time of arterial waveforms using photoacoustic tomography
Time frame
At enrollment (single time point)Sponsors and contacts
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Source ClinicalTrials.gov