Observational Study of Exposure to Environmental Toxicants Among Firefighters
ConditionHealthy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMasonic Cancer Center, University of Minnesota
About this trial
Observational, within subject study design with 1 pre and 2 post-fire exposure biomarker samples collected to assess exposure to toxicants from combustion emissions related to fighting a structural fire.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Firefighter (career or volunteer)
Over 18 years of age
Able to provide written voluntary consent
Disqualifiers
Unwilling to provide a pre and post-exposure urine sample
Current cancer diagnosis
Tobacco use within the last 1 year (verified by urinary TNEs)
Trial population
Firefighters who are exposed to fires containing carcinogens will join this study. Three sample collections will be taken to measure the biomarkers; pre-exposure, 24h post-exposure and 1 week post-exposure.
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
Sample collection
Other interventionThis study will involve three sample collections including buccal cells and urine samples
Treatment groups
60 Participants
are divided into 1 treatment groupGroup A: Firefighters over 18 years old1 intervention
Trial outcomes
Primary outcomes
1
Studying biomarker levels in firefighters pre and post fire call.
The investigators will evaluate the differences between mean pre-exposure biomarker levels and post-exposure levels in urine and buccal samples collected within 24 hours post-exposure and 1-week post-exposure respectively using t-tests to test for statistical significance.
Time frame
48 monthsSponsors and contacts
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Source ClinicalTrials.gov