The goal of this observational study is to evaluate clinical and oncologic outcomes in adult patients undergoing liver and/or biliary resection for benign and malignant diseases.
This study evaluates postoperative morbidity and mortality within 90 days after surgery, as well as overall survival and disease-free survival in patients with malignant disease.
Participants will:
* undergo standard surgical and perioperative management according to routine clinical practice * have clinical, surgical, and follow-up data collected from institutional medical records * be followed for postoperative outcomes and long-term oncologic outcomes up to 5 years
Age ≥ 18 years
Patients undergoing liver resection and/or biliary resection at San Jacopo Hospital, Pistoia
Diagnosis of benign or malignant hepatobiliary disease
Availability of clinical, surgical, and follow-up data
Age < 18 years
Pregnancy
No liver or biliary resection performed
Biopsy only without resection
Adult patients undergoing liver and/or biliary resection for benign or malignant hepatobiliary diseases at San Jacopo Hospital, Pistoia, a high-volume hepatobiliary center. The study includes both a retrospective cohort (2015-2025) and a prospective cohort (2026-2031).
Cohort
Other
Not listed
Postoperative morbidity at 30 days
Postoperative complications classified according to the Clavien-Dindo classification
Postoperative mortality at 30 days
All-cause mortality after liver and/or biliary resection
Postoperative morbidity at 90 days
Postoperative complications classified according to the Clavien-Dindo classification
Postoperative mortality at 90 days
All-cause mortality after liver and/or biliary resection
Severe postoperative complications
Postoperative complications of Clavien-Dindo grade III or higher
Local and distant recurrence rate
Occurrence of local or distant recurrence in patients with malignant disease
Outcomes according to surgical approach
Comparison of outcomes according to surgical approach and extent of resection
Impact of preoperative risk factors
Association of preoperative clinical variables with postoperative and oncologic outcomes
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