Ovarian Hyperstimulation and Fibrin Clot Properties.
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorJagiellonian University
About this trial
The impact evaluation of ovarian hyperstimulation on coagulation and fibrinolysis in infertile women.
Comparative analysis between different ovarian stimulation protocols on thrombin formation and efficiency of fibrinolysis in women diagnosed with infertility.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
infertility defined based on the WHO 2010 criteria
Disqualifiers
ovarian involvement
oral contraceptives use within previous 3 months
dienogest therapy within 3 months until ART
thrombotic events in the medical history
Trial design
Design model
Parallel
Treatments tested in this trial
fibrin clot properties
Diagnostic testAssessment of thrombin generation and efficiency of fibrinolysis.
Treatment groups
300 Participants
are divided into 5 treatment groupsGroup A: Long protocolActive comparator 1 intervention
Group B: Short protocolActive comparator 1 intervention
Group C: Clomiphene citrateActive comparator 1 intervention
Group D: LetrozoleActive comparator 1 intervention
Group E: GonadotropinsActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Fibrin clot properties before and after the ovarian hyperstimulation.
Coagulation (endogenous thrombin potential) and fibrinolysis (F1+2, clot lysis time)parameters assessment.
Time frame
4 monthsSecondary outcomes
1
Endometriosis and fibrin clot properties.
Changes of fibrin clot properties before and after ovarian hyperstimulation in women with endometriosis - Coagulation (endogenous thrombin potential) and fibrinolysis (F1+2, clot lysis time)parameters assessment.
Time frame
1 cycleSponsors and contacts
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Source ClinicalTrials.gov