Oxytocin and Human Defensive Responses in a Dynamic Situation

ConditionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorUniversity of Electronic Science and Technology of China

About this trial

The presnet study is to investigate the effect of intranasal oxytocin (24 IU) treatment on modulating how human responsd to threat in a dynamic situation.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy subjects without past or current psychiatric or neurological disorders

Disqualifiers

History of head injury; pregnant, menstruating, taking oral contraceptives; medical or psychiatric illness,

The presence of metal in the body or claustrophobia.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Oxytocin nasal spray

    Drug

    intranasal administration of oxytocin (24 IU)

  • Placebo

    Drug

    intranasal administration of placebo (24 IU)

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: oxytocin groupExperimental treatment 1 intervention
Group B: placebo groupPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Escape sucess rates when confronting different predators

Escape sucess rates in successfully entering the refuge when confronting the fast, medium and slow predators.

Time frame
1 hour
2

Flight initiation distance

It is the prey-predator distance when a prey flees from a threat, a key index quantifying escape decisions.

Time frame
1 hour
3

The distance to refuge

The distance to refuge when a prey flees from a threat.

Time frame
1 hour
4

Brain activity patterns in response to threats along the predatory imminence continuum

Brain activity patterns in response to different predators along the predatory imminence continuum. We will examine these brain response patterns via both the conventional univariate analysis and the machine learning-based multivariate pattern analysis (MVPA) approaches. Based on previous studies, the medium predator is a priori used as an anchor for fast and slow predators for a more sensitive measure of brain activity differences and contrasts with the medium predator would be reported in the suplemental files for completeness (if there were significant effects).

Time frame
1 hour

Secondary outcomes

1

Confidence rating scores

Participants are asked to rate their confidence levels in successfully escaping from the predator before each block.

Time frame
1 hour
2

Anxiety rating scores

Particioants are asked to rate how anxious they felt during the escape decision-making process.

Time frame
1 hour
3

SCR during task

Skin Conductance Response (SCR) data are recorded in the task during scanning.

Time frame
1 hour

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.