About this trial
The presnet study is to investigate the effect of intranasal oxytocin (24 IU) treatment on modulating how human responsd to threat in a dynamic situation.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy subjects without past or current psychiatric or neurological disorders
Disqualifiers
History of head injury; pregnant, menstruating, taking oral contraceptives; medical or psychiatric illness,
The presence of metal in the body or claustrophobia.
Trial design
Parallel
Treatments tested in this trial
Oxytocin nasal spray
Drugintranasal administration of oxytocin (24 IU)
Placebo
Drugintranasal administration of placebo (24 IU)
Treatment groups
Trial outcomes
Primary outcomes
Escape sucess rates when confronting different predators
Escape sucess rates in successfully entering the refuge when confronting the fast, medium and slow predators.
Flight initiation distance
It is the prey-predator distance when a prey flees from a threat, a key index quantifying escape decisions.
The distance to refuge
The distance to refuge when a prey flees from a threat.
Brain activity patterns in response to threats along the predatory imminence continuum
Brain activity patterns in response to different predators along the predatory imminence continuum. We will examine these brain response patterns via both the conventional univariate analysis and the machine learning-based multivariate pattern analysis (MVPA) approaches. Based on previous studies, the medium predator is a priori used as an anchor for fast and slow predators for a more sensitive measure of brain activity differences and contrasts with the medium predator would be reported in the suplemental files for completeness (if there were significant effects).
Secondary outcomes
Confidence rating scores
Participants are asked to rate their confidence levels in successfully escaping from the predator before each block.
Anxiety rating scores
Particioants are asked to rate how anxious they felt during the escape decision-making process.
SCR during task
Skin Conductance Response (SCR) data are recorded in the task during scanning.
Sponsors and contacts
Click on the lead sponsor to view all of their trials.