Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion
ConditionCritically Ill
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorCairo University
About this trial
Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events. Therefore, the time of weaning should be wisely evaluated. There is growing evidence concerning respiratory muscles dysfunction that contributes to difficulty or prolonged liberation from MV.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
critically ill patient mechanically ventilated for 24 hours or more first spontaneous breathing trial
Disqualifiers
patient refusal difficult ultrasound views tracheostomized patient neuromuscular disorders
Trial design
Design model
Parallel
Treatments tested in this trial
Parasternal intercostal thickening fraction
DeviceParasternal intercostal thickening fraction less than 6.5%
Sham parasternal intercostal thickening
DeviceUltrasound assessment only for purpose of blinding
Treatment groups
200 Participants
are divided into 2 treatment groupsGroup A: Control groupSham comparator 1 intervention
Group B: UltrasoundActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Incidence of reintubation
need for reintubation
Time frame
Within 72 hours after extubationSecondary outcomes
1
Incidence of weaning failure
failed spontaneous breathing trial or reintubation
Time frame
within 72 hours post-extubationLocations
1Map coordinates are unavailable for these locations. Locations are shown below instead.
Cairo UniversityRecruiting6890, Cairo, Giza Governorate
Egypt
EgyptSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov