This study aims to evaluate the clinical applicability of a peri-habilitation program in patients with gastric cancer by applying nutritional intervention for approximately two weeks before surgery and a combined exercise and nutrition intervention for about three weeks after hospital discharge, and by analyzing its effects on the prevention of postoperative complications and recovery.
Patients aged 65 years or older who have been diagnosed with gastric cancer and are scheduled to undergo surgical treatment or chemotherapy.
Patients with severe conditions who are unable to undergo the intervention prior to surgical treatment or chemotherapy.
Patients with physical (e.g., musculoskeletal) or mental disorders that make participation in or continuation of the program impossible.
Patients judged to be at risk of additional physical burden from the intervention.
Parallel
nutrition education plus active supplement
Dietary supplementNutrition Group (NUT) Participants will receive standard clinical care combined with nutrition education and protein-enriched soy milk supplementation for approximately 2 weeks before surgery and about 3 weeks after hospital discharge.
Exercise
BehavioralExercise and Nutrition Participants will receive peri-habilitation exercise training together with nutritional intervention, including carbohydrate plus protein-enriched soy milk supplementation twice daily (before and after exercise), for approximately 2 weeks before surgery and about 3 weeks after hospital discharge.
Gait speed test
* Time to walk 4 meters (or 3 meters) at a normal, comfortable pace. * Seconds(sec) * Lower values(seconds) indicate better performance (faster walking speed)
Chair stand test
* Time to stand up and sit down 5 times from a chair without using the arms. * Seconds(sec) * Lower values(seconds) indicate better performance.
Balance test
* Time maintaining balance in three positions (feet together, semi-tandem, and tandem stance). The maximum time allowed for each position is 10 seconds. * Seconds(sec) * Higher values(seconds) indicate better performance.
Timed up and go test
* Time to stand up from a chair, walk 3 meters, turn around, walk back, and sit down. * Seconds(sec) * Lower values(seconds) indicate better performance.
Electrocardiogram(ECG)
* Cardiovascular status assessed using electrocardiogram (ECG) * N/A (qualitative/clinical assessment) * Abnormal ECG findings indicate impaired cardiovascular function.
Inflammation and Oxidative Stress Markers (Blood Analysis)
* Inflammatory and oxidative stress markers assessed by blood analysis, including C-reactive protein (CRP) and white blood cell(WBC) count. * mg/L for CRP; ×10⁹/L for WBC * Higher values indicate greater systemic inflammation.
Hospital Anxiety and Depression Scale (HADS)
* The scale ranges from 0 to 21 points for each domain (anxiety and depression). Higher scores indicate worse psychological distress. * Score on a scale (0-21) * Higher scores indicate worse psychological condition.
Quality of life(KOQUSS-32, KOQUSS-40)
* Quality of life assessed using the Korean Quality of Life in Stomach Cancer Patient Study group questionnaires (KOQUSS-32 and KOQUSS-40). Each questionnaire provides domain-specific scores. Higher scores indicate better quality of life. * Score on a scale (range depends on quetionnaire) * Higher scores indicate better quality of life.
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Korea University Anam Hospital
Lead sponsor
Korea University
Collaborator
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