Peri-Implant Soft Tissue Integration in Humans: Influence of Material
ConditionHealthy Subjects
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire de Liege
About this trial
The purpose of this study is to compare the mucointegration of 2 types of surface roughness of zirconia abutments with titanium. The surface roughness will be machined and ultra-polished.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Participants have to voluntarily sign the informed consent form before any study related action
Patients aged 18 or over
Patients with one or more missing teeth in the maxillary or mandible area, seeking implant therapy
Men/women
Disqualifiers
Autoimmune disease requiring medical treatment
Medical conditions requiring prolonged use of steroids
Use of Bisphosphonates intravenously or more than 3 years of oral use
Infection (local or systemic) - patients with gingivitis or active local infection will undergo a medical treatment prior to the entrance to the study, and each individual will be evaluated for suitability; in case of a systemic infection, the evaluation will be based on medical anamneses, and if necessary, a patient will be referred to relevant medical tests
Trial design
Design model
Parallel
Treatments tested in this trial
Mucointegration
Other interventionPlacement of abutment on a dental implant to study mucointegration
Treatment groups
40 Participants
are divided into 3 treatment groupsGroup A: Ultra-polished zirconia abutmentExperimental treatment 1 intervention
Group B: Machined zirconia abutmentExperimental treatment 1 intervention
Group C: Titanium abutmentActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Histomorphometry
Height measure of biological width (sulcus depth, epithelial and connective adhesion)
Time frame
8 weeks of healing2
Immunohistology
Analysis of the pro-inflammatory cells and vascularisation of the soft tissue + analysis of the percentage of cells adhesion on the abutment
Time frame
8 weeks of healingSponsors and contacts
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Source ClinicalTrials.gov