Health TrialsbyHealthPanel

Periodization Resistance Training on Quality of Life in Females With Hypothyroidism

ConditionHypothyroidism
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age35-45
SponsorCairo University

About this trial

This study will be conducted to compare between the effect of nonlinear and linear periodized training on quality of life in females with hypothyroidism.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Be controlled hypothyroidism (TSH level within 0.5 - 4.5 mU/L)

Be ranged from 35 to 45 years

Female patients

Body Mass Index 30-34.9 kg/m2 .

Disqualifiers

history of pulmonary disease

Patients with uncontrolled coronary or cerebrovascular disease

Those who underwent musculoskeletal surgery within the previous year

Recent history of lower and upper limb fracture , hip and shoulder dislocation.

Trial design

Design model

Parallel

Treatments tested in this trial

  • non linear periodization exercise

    Other intervention

    The non-linear periodized resistance training program follows a 12-week schedule with varying intensity levels across three training days per week. The intensity fluctuates between very light (VL), light (L), moderate (M), heavy (H), and very heavy (VH) workouts, distributed strategically throughout the week. Each training day implements different intensity levels, and an active rest day follows any workout session.

  • linear periodization exercise

    Other intervention

    The linear periodization exercise program spans 12 weeks with systematically varied training parameters. During weeks 1-2, participants perform 3 sets of 10 repetitions, followed by 3 sets of 8 repetitions in weeks 3-4. The program progresses to 4 sets of 6 repetitions in weeks 5-6, then 3 sets of 6 repetitions during weeks 7-8. The final phases consist of 4 sets of 4 repetitions in weeks 9-10, concluding with 3 sets of 4 repetitions in weeks 11-12. Training loads advance through autoregulatory progression, where participants progress at their individual pace under supervision. While sets and repetitions remain fixed within each phase, load progression is determined by performance in the final set of each exercise, ensuring safe and effective advancement.

  • medical treatment

    Drug

    The medical treatment will be received for 12 weeks.

Treatment groups

75 Participants
are divided into 3 treatment groups
Group A: non linear periodization exercise + medical treatmentExperimental treatment 2 interventions
Group B: linear periodization exercise + medical treatmentExperimental treatment 2 interventions
Group C: medical treatmentActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Serum thyroid stimulating hormone (TSH) level

It will be measured by ELISA kits. This kit is an Enzyme Linked Immunosorbent Assay (ELISA). (Precheck bio, inc, @ EIA KIT, USA).

Time frame
12 weeks
2

FreeT4 (thyroxine) level

It will be measured by ELISA kits. This kit is an Enzyme Linked Immunosorbent Assay (ELISA). (Precheck bio, inc, @ EIA KIT, USA).

Time frame
12 weeks
3

Health related Quality of life questionnaire

The Health related Quality of life will be assessed using short form 12 (SF-12), which uses only 12 questions to measure functional health and well being from the patient's perspective. Scores range from 0 to 100, with higher scores indicating better physical and mental health functioning.

Time frame
12 weeks

Secondary outcomes

1

Triglyceride-glucose (TyG) index

The triglyceride-glucose (TyG) index indirectly assesses insulin resistance through a mathematical model that uses only laboratory data on fasting plasma triglyceride and glucose concentrations. The TyG index will be calculated according to the formula: fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL) /2\].

Time frame
12 weeks
2

Hand grip strength

It will be measured before and after treatment using a hand-held dynamometer (HHD), which offers a reliable and valid method.

Time frame
12 weeks
3

9-item Fatigue Severity Scale (FSS)

It will be used before and after treatment to assess fatigue severity. The FFS is a nine-item unidimensional questionnaire scored on a seven-point Likert scale, with high sum scores indicating greater fatigue.

Time frame
12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov
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