Peroxide Versus Non-Peroxide In-Office Tooth Bleaching: A Randomized Clinical Trial
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorMinia University
About this trial
This randomized clinical trial aims to compare the effectiveness of peroxide and non-peroxide in-office tooth bleaching systems. The study will evaluate tooth whitening efficacy, color durability over time, and tooth sensitivity after treatment. Participants will receive one of the two bleaching treatments and will be followed for six months to assess the clinical outcomes and compare the performance of both systems.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults aged 18-45 years.
Good general health.
Presence of all maxillary anterior teeth free from restorations, caries, or structural defects.
Baseline tooth shade suitable for bleaching assessment.
Disqualifiers
Pregnancy or lactation.
History of tooth hypersensitivity.
Active caries or defective restorations in the anterior teeth.
Intrinsic tooth discoloration (e.g., fluorosis, tetracycline staining).
Trial design
Design model
Parallel
Treatments tested in this trial
peroxide -based in office tooth bleaching
Procedure/SurgeryParticipants will receive an in-office peroxide-based tooth bleaching treatment using the bleaching system according to the manufacturer's instructions.
non-peroxide -based in office tooth bleaching
Procedure/SurgeryParticipants will receive an in-office non- peroxide-based tooth bleaching treatment using the bleaching system according to the manufacturer's instructions.
Treatment groups
50 Participants
are divided into 2 treatment groupsGroup A: Peroxide-based in office bleachingExperimental treatment 1 intervention
Group B: Non-peroxide-based in office bleachingExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Bleaching efficacy measured by Whiteness Index for Dentistry (WID)
Bleaching efficacy will be assessed using the Whiteness Index for Dentistry (WID) obtained by spectrophotometric measurements of the anterior teeth.
Time frame
Baseline, immediately after treatment, 1 month, 3 months, and 6 months after treatment2
Color durability measured by CIEDE2000 color difference (ΔE00)
Color durability will be evaluated using spectrophotometric color measurements and expressed as CIEDE2000 color difference (ΔE00).
Time frame
Baseline, immediately after treatment, 1 month, 3 months, and 6 months after treatment3
Tooth sensitivity assessed using the Visual Analog Scale (VAS)
ooth sensitivity will be evaluated using a 0-10 Visual Analog Scale (VAS), where 0 indicates no pain and 10 indicates the worst possible pain
Time frame
Daily during the 14-day treatment periodSponsors and contacts
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Source ClinicalTrials.gov