About this trial
This is a single-center, non-randomized, open-label, parallel-group study. It will test D-2570 in people with liver problems and in people with healthy livers, to see how the drug moves through the body and whether it is safe.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Voluntarily participate in this study and sign the written informed consent form after full informed consent, and agree to comply with the procedures specified in the study protocol.
Aged 18 to 70 years.
Both males and females are eligible.
Male participants must weigh no less than 50 kg, and female participants must weigh no less than 45 kg.
Disqualifiers
Have undergone any prior surgery that may affect drug absorption, distribution, metabolism, or excretion, which, in the opinion of the investigator, would make the participant unsuitable for enrollment.
Are female and currently lactating, or have a positive serum pregnancy test result at screening or during the study period.
Have a known history of drug or substance abuse, or test positive for drugs of abuse on the urine drug screen.
Have participated in another interventional clinical trial within 3 months prior to screening, or are currently participating in another clinical trial (participants who withdraw from a prior trial before treatment, i.e., were not randomized or did not receive study intervention, may be enrolled in this study).
Trial design
Parallel
Treatments tested in this trial
D-2570
DrugD-2570 tablet, administered orally as a single dose
Treatment groups
Trial outcomes
Primary outcomes
The main PK parameters -Time to maximum measured plasma concentration -Tmax Population pharmacokinetic characteristics of D-2570
The main PK parameters -Time to maximum measured plasma concentration -Tmax
Maximum observed plasma concentration-Cmax
Maximum observed plasma concentration-Cmax
The main PK parameters Half-life -t1/2
The main PK parameters Half-life -t1/2
The main PK parameters#Area under the plasma concentration versus time curve-AUC
The main PK parameters#Area under the plasma concentration versus time curve-AUC
Secondary outcomes
Incidence of adverse events
Incidence of adverse events
Sponsors and contacts
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