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Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans

ConditionAcanthosis Nigricans
Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-50
SponsorAl-Azhar University

About this trial

evaluate and compare the clinical Efficacy \& Safety Of Fractional Carbon Dioxide (Co₂) Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

- male or female patients aged 18-50 years

clinically & dermoscopy diagnosed acanthosis nigricans involving the neck

skin types iii-v

stable systemic condition for at least 3 months

Disqualifiers

- pregnancy or lactation

malignancy-associated acanthosis nigricans

active skin infection or inflammatory dermatosis at the treatment site

history of keloid or hypertrophic scar formation

Trial design

Design model

Single group

Treatments tested in this trial

  • Topical metformin

    Drug

    applied to one half of the neck only

Treatment groups

34 Participants
are divided into 1 treatment group
Group A: Fractional CO₂ laserActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Assessment of severity using the acanthosis nigricans area and severity index (ANASI) score at baseline and after completion of treatment

Time frame
5-7 days

Secondary outcomes

1

Physician global assessment (PGA)

Time frame
5-7 days

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Al-Azhar University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: