Efficacy of Formulated Eggshell Derived Nano-hydroxyapatite Containing Toothpaste With and Without Addition of Fluoride vs. Conventional Desensitizing Fluoride Containing Toothpaste in Management of Dentin Hypersensitivity

Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-60
SponsorCairo University

About this trial

compare the effectiveness of Eggshell derived nano-Hydroxyapatite with and without fluoride and conventional fluoride containing tooth paste versus conventional desensitizing fluoride containing tooth paste on dentinal tubule occlusion and dentin mineral deposition.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adult Patients Aged 18-60

Males or females.

Good oral hygiene

Absence of abnormal occlusion habits (e.g. bruxism, nail biting, tooth clenching and mouth breathing).

Disqualifiers

Patients with known allergic or adverse reaction to the tested materials.

Systematic disease that may affect participation.

Xerostomic patients.

Patients with bad oral hygiene

Trial design

Design model

Parallel

Treatments tested in this trial

  • Eggshell derived Nano-hydroxyapatite (n-HAp) with a Fluoride containing toothpaste

    Drug

    patients would be instructed to treat their teeth for 5 min twice a day with the provided toothpaste.

  • Eggshell derived Nano-hydroxyapatite (n-HAp) without a Fluoride containing toothpaste

    Drug

    patients would be instructed to treat their teeth for 5 min twice a day with the provided toothpaste.

Treatment groups

39 Participants
are divided into 3 treatment groups
Group A: Eggshell derived Nano-hydroxyapatite (n-HAp) with Fluoride containing toothpasteExperimental treatment 1 intervention
Group B: Eggshell derived Nano-hydroxyapatite (n-HAp) without Fluoride containing toothpasteExperimental treatment 1 intervention
Group C: Commercially available Fluoride containing toothpaste (Sensodyne Rapid Relief)Active comparator 1 intervention

Trial outcomes

Primary outcomes

1

Pain intensity due to Dentin Hypersensitivity by Visual Analogue Scale (VAS)

VAS is used to "quantify" the pain severity in millimeter (mm) in response to such query as "Draw a line on the scale that shows how much pain you have at this time " with "no pain" on the far left end of scale at 0 mm and "pain as bad as it can be" on the far right at 100 mm.

Time frame
T (Time): T0= Baseline (before treatment). T1= 7 days. T2= 3 months. T3= 6 months

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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