Protocols for Magnesium Sulfate Maintenance Dose in Overweight and Obese Women Diagnosed With Preeclampsia

ConditionSevere Preeclampsia

Trial statusNot yet recruiting

Trial phasePhase 1, Phase 2

Trial typeInterventional

Biological sexFemale

Age20-40

SponsorAin Shams University

About this trial

There is still no evidence of the appropriate dose to be used. Serum magnesium sulfate concentration is not measured regularly, thus we may be using sub-therapeutic level or reaching a toxic level.Overweight and obese women have different pharmacokinetics and different drug distribution, therefore, they may need higher doses of magnesium sulfate to reach therapeutic level.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 20-40 years

BMI >25kg/m2

Gestational age > 28 weeks

Disqualifiers

Intrauterine Fetal Death (IUFD)

Hemolysis - Elevated liver enzymes - Low platelets syndrome (HELLP)

Contraindication to Magnesium Sulfate such as myasthenia gravis, severe renal failure, cardiac ischemia, and heart block

Serum creatinine levels greater than 1.1 mg/dL.

Trial design

Design model

Parallel

Treatments tested in this trial

maintenance magnesium sulphate1g/h
Drug
Women will receive a routine loading infusion of 5 g of MgSO4 over 20 minutes, followed by a maintenance dose rate of 1 g/h.
maintenance magnesium sulphate2g/h
Drug
Women will receive a routine loading infusion of 5 g of MgSO4 over 20 minutes, followed by a maintenance dose rate of 2 g/h.

Treatment groups

100 Participants

are divided into 2 treatment groups

Group A: Magnesium Sulphate 1g/hrActive comparator 1 intervention

Group B: Magnesium Sulphate 2g/hrActive comparator 1 intervention

Trial outcomes

Primary outcomes

serum magnesium level

Maternal Serum Magnesium Level after 24 hours of magnesium sulphate infusion

Time frame

24 hours

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ain Shams University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: