Traditional Chinese Medicine focuses on the main pathogenesis of liver depression and spleen deficiency, and treats them from the perspective of soothing the liver and strengthening the spleen to treat on Diarrhea-predominant irritable bowel syndrome (IBS-D) . The classic formula for treating is the Tong-Xie-Yao-Fang (TXYF). Based on metabolomics and metagenomics, the research group studied the intestinal flora and host co metabolism of TXYF in the treatment of diarrhea predominant IBS-D, in order to clarify the mechanism of TXYF in the treatment of IBS-D.
IBS-D patients and healthy volunteers meeting diagnostic criteria;
Aged between 18 and 70;
Have not taken antibiotics, steroids and other hormones, Chinese herbal preparations (including oral and intravenous injections), microecological preparations or probiotics such as yogurt in the past week.
Patients sign informed consent forms and are willing to receive appropriate treatment, and volunteers are willing to cooperate in taking blood, urine, stool and other samples.
Patients with serious heart, liver, kidney and other major organ diseases, hematopoietic system, nervous system or mental diseases;
Other organic diseases of the digestive system (such as peptic ulcers), organic diseases such as tumors indicated by recent colonoscopy, or systemic diseases affecting digestive motility (such as hyperthyroidism, diabetes);
Need to continue to use drugs that may affect gastrointestinal function (antidiarrheals, antidepressants, anti-anxiety drugs, intestinal flora regulation drugs, antibiotics, etc.);
Have a history of drug allergy or severe food allergy for research purposes;
Parallel
Tong-Xie-Yao-Fang
DrugTong-Xie-Yao-Fang granules were taken 2 bags at a time, 2 times per day at 1h after meal for 4 weeks.
Fecal metagenomic detection of bacteria associated with Trp metabolism
Serum detection by Elisa
Serum Trp metabolism was measured by metabolomics
Th17/Treg ratio in peripheral blood was measured by flow cytometry
Click on the lead sponsor to view all of their trials.
