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Clinical and Radiographic Evaluation of Indirect Pulp Capping Using Platelet Rich Fibrin Versus Mineral Trioxide Aggregate in Deep Carious Molars: a Randomized Controlled Trial

ConditionsDental CariesPulp CapingIndirect Pulp TreatmentIndirect Pulp CapIndirect Pulp CappingIndirect Pulp TherapyDeep Carious LesionDeep Carious LesionsMolar CariesCarious Molars
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age20-40
SponsorCairo University

About this trial

The aim of this study is the clinical and radiographic evaluation of (Platelet-Rich Fibrin (PRF) versus Mineral Trioxide Aggregate (MTA) in indirect pulp capping when used with deep carious molars over 1 year follow up.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

o Patients with asymptomatic deep carious molars.

Patients with clinically and radiographically confirmed deep carious lesions that do not exhibit spontaneous pain.

Permanent molars only.

Teeth with intact or minimally restored occlusal surfaces (i.e., no extensive restorations or fractures).

Disqualifiers

o Patients with systemic conditions affecting bone or tissue healing (e.g., uncontrolled diabetes, osteoporosis, immunosuppressed conditions).

Pregnant or lactating women (if applicable to your study).

Teeth with pulp exposure or necrotic pulp.

Presence of symptomatic irreversible pulpitis (e.g., spontaneous pain, lingering pain).

Trial design

Design model

Parallel

Treatments tested in this trial

  • MTA

    Drug

    The indirect pulp capping will be applied using MTA using an MTA carrier, then glass ionomer will be applied, then composite restoration above

  • PRF

    Biological/Vaccine

    The indirect pulp capping will be applied using PRF on a membrane, then glass ionomer will be applied , then composite restoration above

Treatment groups

50 Participants
are divided into 2 treatment groups
Group A: Deep carious molars, indirect pulp capping using PRF then GI base then composite restorationExperimental treatment 1 intervention
Group B: Deep carious molars, indirect pulp capping using MTA then GI base then composite restorationActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Pulp sensibility using cold test

clinical finding of the investigated tooth measured with binary (yes or no)

Time frame
baseline, 3 , 6, 12 months

Secondary outcomes

1

Radiographic finding

Digital Periapical using paralleling technique (Dentin bridge measurement in mm using digital radiographic ruler)

Time frame
baseline, 3 , 6, 12 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: