Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With PDRN Versus Fractional CO₂ Laser

ConditionFacial Scarring

Trial statusRecruiting

Trial phasePhase 2

Trial typeInterventional

Biological sexAll

Age18-50

SponsorMisr University for Science and Technology

About this trial

Facial scars are frequently deemed unpleasant and can profoundly impact a patient's psychological health. This study compares the effectiveness, safety, and capacity to speed up scar healing in the maxillofacial region between fractional carbon dioxide (CO₂) laser therapy alone and polydeoxyribonucleotide (PDRN) combined with CO₂ laser therapy.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age Limitations: Participants must be between 18 and 50 years of age.

Recently cut wounds or surgical scars from about (1-6 months).

Consent to Participate: Willingness to provide informed consent and engage in all aspects of the study.

Disqualifiers

Pregnancy or breastfeeding at the time of study.

Known allergy to PDRN.

Isotretinoin.

Anticancer drugs.

Trial design

Design model

Parallel

Treatments tested in this trial

Polydeoxyribonucleotide
Drug
intralesional PDRN injections
Fractional CO2 laser assisted PDT
Device
Fractional carbon dioxide (CO₂) laser therapy for facial scars

Treatment groups

36 Participants

are divided into 2 treatment groups

Group A: Fractional Carbon Dioxide Laser Combined with Polydeoxyribonucleotide (PDRN)Active comparator 2 interventions

Group B: Fractional CO₂ laser therapy with placebo saline injectionPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

Vancouver Scar Scale

The study used the standard Vancouver Scar Scale, which evaluates four characteristics of scars: Total Score Range: 0 (normal skin) to 13 (severe hypertrophic scar)

Time frame

4 months

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Misr University for Science and Technology

Lead sponsor

Source ClinicalTrials.gov

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