This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo.
It aims to evaluate both clinical and histopathological outcomes in 30 patients with non-segmental stable vitiligo.
Vitiligo is a chronic depigmenting disorder caused by melanocyte destruction with significant psychosocial impact.
The study also investigates immunohistochemical changes, particularly Wnt/β-catenin signaling expression in lesional skin.
The combination therapy is expected to enhance repigmentation by improving melanocyte activation, drug delivery, and angiogenesis
Patients with stable non-segmental vitiligo
No new lesions
No enlargement of existing lesions
Patients of both sexes
Active vitiligo
Pregnant or lactating women
History of keloid formation
Hematological disorders
Factorial
microneedling with minoxidil 5% and NBUVB
Combination productMicronnedlin depth 1% then topical Minoxidil5% and Narrow Band UVB
Microneedling with Minoxidil5%
Combination productMicroneedling with topical Minoxidil 5%
Repigmentation in the vitiliginous area after receiving the treatment and increasing the wnt b catenin marker level in the histopathological specimen
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This trial is not recruiting at the moment. You can still explore other options:
