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Evaluation of iPRF With Vit.D As an Adjunct to Non-Surgical Therapy in the Treatment of Stage III Periodontitis

ConditionPeriodontal Pocket
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorCairo University

About this trial

a clinical trial will be made to investigate the effect of locally applied injectable prf (iPRF) plus vitamin D on the periodontal pockets in stage III periodontitis patients

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients with healthy systemic condition.

Adult patients ˃ 18 years old.

Patients with Stage III periodontitis.

Patients accept 3-month follow-up period (cooperative patients).

Disqualifiers

Presence of prosthetic crowns.

Extensive interproximal restorations.

Periodontal therapy within the last 12 months.

Having undergone surgical periodontal therapy or undergoing orthodontic treatment.

Trial design

Design model

Factorial

Treatments tested in this trial

  • PMPR+iPRF

    Procedure/Surgery

    locally applied iPRF in the periodontal pocket

  • PMPR+iPRF+Vit.D

    Drug

    locally applied iPRF plus vitamin D in the periodontal pocket

  • PMPR only

    Procedure/Surgery

    scaling and root planing only will be done for the periodontal pocket for the control group

Treatment groups

45 Participants
are divided into 3 treatment groups
Group A: PMPR onlyActive comparator 1 intervention
Group B: PMPR + iPRFExperimental treatment 1 intervention
Group C: PMPR + iPRF + Vit.DExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

pocket depth reduction

estimate the amount of reduction of the pocket depth from baseline and after 6 months of treatment

Time frame
6 months

Secondary outcomes

1

clinical attachment level (CAL) gain

the amount of CAL gained from baseline and after 6 months of treatment

Time frame
6 months
2

Plaque index

comparison of amount of plaque before and after treatment using plaque score

Time frame
6 months
3

Bleeding on probing (BOP)

measuring the percentage of BOP using a periodontal probe before and after treatment

Time frame
6 months
4

Gingival Marginal Level (GML)

determining the location of gingival margin in relation to the tooth before and after treatment

Time frame
6 months

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: