This randomised, single-masked, parallel-group clinical trial will evaluate the efficacy and safety of a topical triamcinolone acetonide-loaded polymeric nanocapsule formulation for postoperative care following endoscopic nasal surgery.
Participants will receive either the investigational triamcinolone acetonide-loaded nanocapsule formulation or standard normal saline nasal irrigation. Postoperative nasal healing, inflammation, patient-reported sinonasal symptoms, postoperative complications, and corticosteroid-related adverse effects will be compared between the two groups.
Adults aged 18 to 60 years.
Functional endoscopic sinus surgery
Endoscopic turbinoplasty
Endoscopic septoplasty
Known hypersensitivity to triamcinolone acetonide.
Known hypersensitivity to any component of the polymeric nanocapsule formulation.
Systemic contraindication to corticosteroid therapy.
Active severe nasal or sinonasal infection at the time of enrollment or treatment.