Clinical trials

This randomized controlled superiority trial evaluates the anti-otomycotic efficacy of Prunus salicina methanolic extract in two formulations (standard drops and chitosan nanoparticle-based drops) compared to standard 1% clotrimazole drops in patients diagnosed with otomycosis.

This observational study will evaluate whether a smartphone's built-in accelerometer can provide accurate and repeatable measurements of walking in children with unilateral spastic cerebral palsy. Thirty-five children aged 6 to 12 years will complete two walking trials along a 10-meter indoor walkway at their usual comfortable speed. During each trial, a smartphone will be secured over the lower back at the L4-L5 level to record body acceleration using the Phyphox application. At the same time, a video camera will record the child's walking for analysis using Kinovea software. Measurements obtained from the smartphone will be compared with measurements obtained from video analysis. The study will assess walking velocity, cadence, stride timing, and gait asymmetry. The two repeated walking trials will also be used to determine whether the smartphone measurements are consistent when the test is repeated during the same session. The study does not involve any treatment or change to the child's usual medical or physical therapy care. The purpose is to determine whether smartphone-based gait assessment may be a practical, low-cost method for evaluating walking in children with unilateral spastic cerebral palsy.

This randomised, single-masked, parallel-group clinical trial will evaluate the efficacy and safety of a topical triamcinolone acetonide-loaded polymeric nanocapsule formulation for postoperative care following endoscopic nasal surgery. Participants will receive either the investigational triamcinolone acetonide-loaded nanocapsule formulation or standard normal saline nasal irrigation. Postoperative nasal healing, inflammation, patient-reported sinonasal symptoms, postoperative complications, and corticosteroid-related adverse effects will be compared between the two groups.

In consistence of North Africa vision to decrease incidence of NCDs in different population type investigators decide to give more concerns to youth (young old) who are the main human power to build future. Recent data report non-communicable diseases (NCDs) are the current leading cause of mortality in Egypt, with NCDs estimated to account for 85% of all deaths. Egypt's youth population (16-25 years old) is both the country's greatest asset and one of its biggest challenges. This age group makes up a huge share of the population, and while they are more connected to technology, social media, and modern facilities than older generations, they face lifestyle barriers that affect their health and productivity. Many modifiable risk factors affect their behavior and in consequence health. These factors related strongly to their close relationship with technology, they spend more time on mobile and computer applications that affect directly on physical inactivity, sleeping time (onset and duration) and at the end cause NCDs as obesity and CVs problems. Upper Egypt as apart from North Africa region is considered as one of the low-income countries with special cultures, specifically regarding food and physical activities. Even though young people constitute a significant proportion of the population, comparatively fewer studies have examined the prevalence of health concerns and the strategies needed to promote their well-being, especially when contrasted with research focused on groups such as the elderly or pregnant and lactating women. This project aims to investigate prevalence patterns, identify contributing factors, enhance community awareness by encouraging training of healthcare providers to best act and modify youth risk factors, and implement preventive interventions that are both cost-effective and sustainable. Furthermore, it seeks to foster adherence to these measures to strengthen health literacy and reduce the burden of conditions

Nonspecific neck pain, defined as pain without a specific underlying pathology, is a common musculoskeletal disorder that affects a significant proportion of the global population. Neck pain often results in considerable discomfort and functional limitations, impacting individuals' quality of life and ability to perform daily tasks. Estimates suggest that up to 30% of adults experience neck pain annually. The condition ranks among the top causes of disability worldwide, contributing to substantial personal and societal burdens, including lost work productivity and increased healthcare costs.