Yeast Protein for Muscle Mass

ConditionHealthy Adult Participants

Trial statusNot yet recruiting

Trial phasePhase 2, Phase 3

Trial typeInterventional

Biological sexAll

Age18-35

SponsorUniversity of Alberta

About this trial

Protein supplementation is said to be one of the cost-efficient and practical strategies to meet protein needs for growth and exercise, and can help maximize muscle gain from resistance exercise. It facilitates faster recovery from stress-induced tissue damage and enhances performance output. Protein sources derived from animal products are generally recognized as the highest quality protein. However, altering the protein composition of a protein source can improve the protein quality. The yeast protein supplement the investigators will use in this study has a similar amino acid composition to whey protein, which is derived from an animal product, but it is produced more sustainably. The study aims to compare the effects of yeast and whey protein on muscle mass over 16 weeks.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Participants must have the ability to read, understand, and sign an informed consent form and must be willing to comply with study treatment and follow-up.

Prior resistance training experience (defined as performing resistance exercises >1/week for the past 3 months or longer) to enable them to reach a large training stimulus relatively quickly and to avoid the longer phase of neuromuscular adaptations

≥18 years and <35 years of age

Disqualifiers

Diabetes, musculoskeletal disease, cancer, Crohn's disease, or any other acute or chronic condition that interferes (or the medication prescribed for those conditions) with muscle anabolism.

Diagnosed with or being treated for heart disease, stroke, high blood pressure 130/80 mmHg or higher

Pain/discomfort/pressure in the chest during activities of daily living or physical activity

Pregnant or not on adequate contraception.

Trial design

Design model

Parallel

Treatments tested in this trial

Yeast Protein
Dietary supplement
60g of protein supplement (40g of protein). Oral administration, 30g during exercise and anytime after exercise, or 30g in the morning and evening if no exercise is performed for a period of 16 weeks.
Resistance Training Exercises
Other intervention
Lower and upper body resistance training exercises 3 times a week for 16 weeks
Whey Protein
Dietary supplement
60g of protein supplement (40g of protein). Oral administration, 30g during exercise and anytime after exercise, or 30g in the morning and evening if no exercise is performed for a period of 16 weeks.

Treatment groups

72 Participants

are divided into 2 treatment groups

Group A: Whey ProteinActive comparator 2 interventions

Group B: Yeast ProteinExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

Changes in muscle mass

The primary outcome of the study is the change in muscle mass. It is hypothesized that participants consuming yeast protein will show an increase in appendicular lean mass similar to that observed with whey protein.

Time frame

16 weeks

Secondary outcomes

Changes in muscle function, resting energy expenditure, inflammatory biomarkers, oxidative stress markers, gut microbiota, and metabolites

The secondary outcomes of the study include changes in muscle function, which will be assessed through one-repetition maximum (1RM) testing for both the bench press and leg press. Additionally, the investigators will evaluate resting energy expenditure, inflammatory biomarkers, specifically plasma cytokines, as well as oxidative stress markers such as glutathione, total antioxidant capacity, and protein carbonyl levels. The study will also investigate gut microbiota and metabolites. The investigators hypothesize that the secondary outcomes will show similar effects in participants taking yeast protein compared to those taking whey protein.

Time frame

16 weeks

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Alberta

Lead sponsor

Source ClinicalTrials.gov

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