A randomized clinical trial to assess the efficiency of acetylsalicylic acid (aspirin) 150 mg/day started before 20 weeks of gestation in the prevention on maternal and fœtal complications in pregnant women with chronic hypertension.
Pregnant patient between 10 and 19 weeks of gestation + 6 days
Chronic hypertension, whether treated or not, know before pregnancy or diagnosed before randomization
Singleton pregnancy
Signed the written informed consent
---Medical history requiring anticoagulation (antiphospholipid syndrome, deep vein thromboembolic disease, pulmonary embolism, atherothrombosis, patient with mechanical heart valves),
Patient receiving aspirin for another indication outside pregnancy,
Patient with significant proteinuria (> 300mg/24 hours or a proteinuria/creatininuria ratio ≥ 30mg/mmol),
Active bleeding,
Parallel
Aspirin 150 mg
DrugTreatment assigned by randomization will be prescribed immediately and continued throughout pregnancy up to 35 weeks + 6 days for both groups. The active or placebo will be dispensed by the centre's pharmacy. Treatment will be taken in the evening. A daily log is given to patients and must be completed every day.
Placebo
DrugTreatment assigned by randomization will be prescribed immediately and continued throughout pregnancy up to 35 weeks + 6 days for both groups. The active or placebo will be dispensed by the centre's pharmacy. Treatment will be taken in the evening. A daily log is given to patients and must be completed every day.
Composite morbidity-mortality criterion including preeclampsia, intra-uterine growth retardation <10th percentile, placental abruption, Preterm birth < 37 weeks of gestation, Perinatal death, Maternal death
A composite morbidity-mortality criterion that includes the occurrence during pregnancy or postpartum of at least one of the following events: preeclampsia, IUGR \<10th percentile, placental abruption, Preterm birth \< 37 weeks of gestation, Perinatal death (death from 22 weeks of gestation until 28 days after birth), Maternal death
IUGR (< 10th percentile of birth weight)
Rate of IUGR (\< 10th percentile of birth weight)
Placental abruption
Rate of placental abruption
Preterm birth < 37 weeks of gestation
Rate of severe preterm delivery (\< 37 weeks of gestation)
Maternal death
Rate of severe maternal death
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