Dexmedetomidine and Bupivacaine Intra-articular for Postoperative Analgesia After Knee Arthroscopic Surgery

ConditionPost Operative Analgesia

Trial statusRecruiting

Trial phasePhase 3

Trial typeInterventional

Biological sexAll

Age18-65

SponsorAl-Azhar University

About this trial

The aim of this study to compare the analgesic effects of intraarticular dexmedetomidine added to bupivacaine with those of bupivacaine alone after knee arthroscopy

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

ASA I-II patients

Either sex

Aged 18-65 years

Candidates for anterior cruciate ligament (ACL) reconstruction by knee arthroscopy

Disqualifiers

the patients with kidney failure, liver failure, valvular and ischemic heart disease , high blood pressure, diabetes, history of infection and malignancy.

history of coagulation diseases, and history of drug allergies to used drugs.

those who consumed NSAIDs and analgesics 24 h before surgery were excluded from the study.

Trial design

Design model

Parallel

Treatments tested in this trial

Normal Saline (Placebo)
Drug
the 18 ml of normal saline will injected intra articular in the knee joint by the surgeon through the arthroscope after completing the procedure
Bupivacaine 0.25%
Drug
the 18ml 0.25% bupivacaine. will injected intra articular in the knee joint by the surgeon through the arthroscope after completing the procedure
Dexmedetomidine
Drug
Dexmedetomidine 1 μg/kg will injected intra articular in the knee joint by the surgeon through the arthroscope after completing the procedure.

Treatment groups

75 Participants

are divided into 3 treatment groups

Group A: group of control (C)Experimental treatment 1 intervention

Group B: groups of Bupivacaine (B)Experimental treatment 2 interventions

Group C: groups of dexmedetomidine (D)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

Change on the visual analog scale (VAS) for pain (0 = no pain to 100 = the maximum pain )to assessment the duration of analgesia following the surgery

Change on the visual analog scale (VAS) for pain (0 = no pain to 100 = the maximum pain) to assessment the duration of analgesia following intra articular injection of Bupivacaine and Dexmedetomidine after knee arthroscopy

Time frame

post operative at 30 minute, 1 hour, 2 hour, 4 hour, 6 hour, 12 hour, and 24 hour .

Secondary outcomes

Total meperidine consumption . Meperidine will be used intravenously if the visual analog scale ( VAS) score was >50 to control postoperative pain.

the secondary outcome variables will be the total dose of meperidine given between the study groups.Meperidine will be used intravenously if the visual analog scale ( VAS) score was \>50 to control postoperative pain.

Time frame

The total dose of meperidine given between the study groups during the first 24 hour( post operative at 30 minute, 1 hour, 2 hour, 4 hour, 6 hour, 12 hour, and 24 hour),will be recorded.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Al-Azhar University

Lead sponsor

Source ClinicalTrials.gov

Apply now