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Evaluation of The Periodontal Parameters Following Non-Surgical Periodontal Therapy With and Without Adjunctive Use of Injectable Platelet Rich Fibrin: A Randomized Controlled Clinical Trial

ConditionPeriodontitis (Stage 3)
Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
AgeUp to 70
SponsorCairo University

About this trial

This randomized controlled clinical trial aims to evaluate the effectiveness of non-surgical periodontal therapy (NSPT) with and without the adjunctive use of injectable platelet-rich fibrin (I-PRF) in patients with chronic periodontitis. The primary objective is to assess changes in key periodontal parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI) over a defined follow-up period. Participants will be randomly assigned to two groups: one receiving standard NSPT alone and the other receiving NSPT combined with subgingival application of I-PRF. The study seeks to determine whether the adjunctive use of I-PRF can enhance periodontal healing and improve clinical outcomes compared to conventional therapy alone.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

Systemic disease, Smoking, Pregnancy, History of Chemotherapy, Radiotherapy

Trial design

Design model

Parallel

Treatments tested in this trial

  • non-surgical periodontal therapy

    Procedure/Surgery

    Mechanical Root Instrumentation using Ultrasonic scaling and root debridement using Gracey Curettes

  • non-surgical periodontal therapy + I-PRF

    Procedure/Surgery

    Mechanical Root Instrumentation using Ultrasonic scaling and root debridement using Gracey Curettes following by subgingival application of I-PRF

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: Non-surgical Periodontal TherapyActive comparator 1 intervention
Group B: Non-surgical Periodontal Therapy + Injectable Platelet Rich FibrinExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Clinical attachment Gain

the change in the distance from the Cemento-Enamel Junction to the base of the periodontal pockets

Time frame
3 months

Secondary outcomes

1

Probing Depth Reduction

The change in the distance from the gingival margin to the base of the periodontal pocket

Time frame
3 months
2

Bleeding on Probing

the response to the walking of the probe on the lateral wall of the periodontal pocket

Time frame
3 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Gulf Medical University

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: