Intralesional Acyclovir Versus Intralesional Zinc Sulphate in the Treatment of Plantar Warts

Trial design

Treatments tested in this trial

• Intralesional Acyclovir

  Drug DrugA medicine being studied. This category can also include a placebo used for comparison.

  Intralesional injection of acyclovir, prepared using 250 mg acyclovir vial diluted with 3.5 ml saline (yielding an acyclovir concentration of approximately 70 mg/ml), at a dose of (0.1- 0.3 ml) injected into the largest (target) wart under aseptic precautions using an insulin syringe. The injection will be repeated every 2 weeks until complete clearance of warts or for a maximum of five sessions.

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• Intralesional Zinc Sulphate

  Drug DrugA medicine being studied. This category can also include a placebo used for comparison.

  Intralesional injection of 2% zinc sulphate prepared using 2 gm of zinc sulphate powder dissolved in 100 ml of sterile distilled water and autoclaved at 95°C for 20 minutes, at a dose of (0.1- 0.3 ml) in the base of the largest (target) wart . The wart is injected with the solution till blanching or bleb formation. Subcutaneous injections and acral parts such as fingers and toes will be avoided, as it may cause vascular necrosis. Injections will be repeated for all patients into the same lesion every 2 weeks until complete clearance of warts or for a maximum of five sessions.

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