Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation)

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorMuhammad Ali Javed

About this trial

The goal of this clinical trial is to learn whether intravenous verapamil or intravenous metoprolol controls heart rate more effectively in adult patients who arrive at the emergency department with atrial fibrillation and a fast heart rate (rapid ventricular response), but who are otherwise medically stable. Atrial fibrillation with a rapid heart rate is a common emergency, and doctors currently choose between these two standard medicines based on personal preference rather than strong local evidence, since there is limited research on this comparison in Pakistani patients.

The main questions this study aims to answer are:

Does a higher proportion of patients reach a target heart rate of less than 110 beats per minute within 30 minutes with verapamil compared to metoprolol? Which medicine controls the heart rate faster, on average? Are there differences in side effects (such as low blood pressure, slow heart rate, or breathing problems) between the two medicines? Researchers will compare a group of patients receiving verapamil to a group receiving metoprolol to see if one medicine controls the heart rate faster and more safely than the other.

Participants will:

1. Receive either verapamil or metoprolol through an IV, with the dose given according to standard protocols 2. Have their heart rate, blood pressure, and oxygen levels monitored continuously for 30 minutes after the medicine is given 3. Be observed for any side effects during this monitoring period Both medicines used in this study are already standard, guideline-recommended treatments for this condition, so participation will not change or delay the medical care patients would normally receive.

Eligibility criteria

Qualifiers

Adult patients aged 18 years and above presenting to the Emergency Department

Confirmed diagnosis of atrial fibrillation with rapid ventricular response (heart rate ≥110 bpm) on 12-lead ECG

Hemodynamically stable at the time of enrollment (systolic blood pressure ≥90 mmHg, no shock, no acute pulmonary edema)

Willingness to provide written informed consent

Disqualifiers

Hemodynamic instability, cardiogenic shock, or acute decompensated heart failure

Known pre-excitation syndrome (e.g., Wolff-Parkinson-White syndrome) on baseline ECG

Severe left ventricular systolic dysfunction (ejection fraction less than 30%) as determined by echocardiography

Known hypersensitivity or contraindication to verapamil or metoprolol

Trial design

Treatments tested in this trial

  • Verapamil Hydrochloride
  • Metoprolol tartrate

Treatment groups

120 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

Muhammad Ali Javed

Lead sponsor

Wah Medical college , POF hospital

Sponsor institution