This study aimed to assess the effectiveness of Coenzyme Q10 in preventing both acute and chronic pain following thoracoscopic surgery, with a focus on its potential benefits in reducing the incidence and severity of pain.
Aged 18-75 years;
American Society of Anesthesiology (ASA) physical status classification I-III;
Scheduled for elective lung resection surgery under thoracoscopy;
Voluntarily opting for patient-controlled intravenous analgesia;
History of previous thoracotomy or thoracoscopic surgery;
Patients converted to open thoracotomy intraoperatively;
Severe hepatic or renal dysfunction;
History of substance abuse;
Parallel
Coenzyme Q10
DrugCoenzyme Q10 was administered from admission to one month after discharge at a dose of 200 mg per day (200 mg/qd).
Placebo
Other interventionThe placebo was administered from hospital admission until one month after discharge.
The incidence of chronic postsurgical pain
The incidence of acute postoperative pain with a score ≥4
Use pain Numeric Rating Scale(NRS) to evaluate the movement-evoked pain score and rest pain score. (NRS scale 0-10, where 0 was no pain, and 10 was the worst possible pain)
The severity of acute postoperative pain
Use pain Numeric Rating Scale(NRS) to evaluate the movement-evoked pain score and rest pain score.(NRS scale 0-10, where 0 was no pain, and 10 was the worst possible pain)
The severity of chronic postsurgical pain
Use pain Numeric Rating Scale(NRS) to evaluate the movement-evoked pain score and rest pain score.(NRS scale 0-10, where 0 was no pain, and 10 was the worst possible pain)
The incidence of neuropathic pain
The DN4 questionnaire (Douleur Neuropathique 4) was used to evaluate neuropathic pain. The DN4 is a validated diagnostic tool consisting of 10 items, with scores ranging from 0 to 10. A score of 4 or higher indicates the presence of neuropathic pain.
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