The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery

ConditionsKnee Arthroplasty, Total Knee Arthritis, Osteoarthritis Total Knee Anthroplasty Blood Loss Tranexamic Acid Use Epinephrine

Trial statusRecruiting

Trial phasePhase 4

Trial typeInterventional

Biological sexAll

Age18-70

SponsorKing Abdullah International Medical Research Center

About this trial

The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty.

Also aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients undergoing knee joint arthroplasty.

Saudi and Non-Saudi Patient.

Patients who have Complete medical record.

Disqualifiers

End stage renal disease

Liver cirrhosis

Coagulopathy

Pre-operative Hgb <10 5.

Trial design

Design model

Parallel

Treatments tested in this trial

low-dose epinephrine and tranexamic acid
Drug
low-dose epinephrine and tranexamic acid
Tranexamic Acid (TXA) treatment
Drug
Tranexamic Acid

Treatment groups

80 Participants

are divided into 2 treatment groups

Group A: Epinephrine + Tranexamic Acid GroupExperimental treatment 1 intervention

Group B: Tranexamic Acid GroupActive comparator 1 intervention

Trial outcomes

Primary outcomes

Perioperative blood loss

Calculated 24 h blood loss in mL, Hidden blood loss in mL, Hemoglobin levels in g/dL, Hematocrit levels as a percentage, Platelets count in cells/µL.

Time frame