Health TrialsbyHealthPanel

Phenotyping Genetic Risk for Type 2 Diabetes

ConditionsDiabetes Mellitus, Type 2Genetics
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age10-70
SponsorUniversity of Pennsylvania

About this trial

This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age 10-70 years

Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.

Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher

Disqualifiers

prior diagnosis of type 1, type 2, or secondary diabetes

use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication

acute illness that may impact insulin and glucose dynamics

pregnancy

Trial design

Design model

Single group

Treatments tested in this trial

  • 75g glucose beverage (Glucola, Trutol, or similar brand)

    Other intervention

    Subjects will present fasting to the study day and ingest the glucose beverage during the oral glucose tolerance test.

  • DXA, whole body

    Other intervention

    Subjects will undergo a whole body DXA scan for assessment of adiposity index and body fat distribution.

Treatment groups

100 Participants
are divided into 1 treatment group
Group A: PhenotypingOther 2 interventions

Trial outcomes

Primary outcomes

1

Glucose response to an oral glucose load

Glucose area under the curve after the 75g glucose beverage

Time frame
samples will be collected over four hours and these results will be used to calculate area under the curve

Secondary outcomes

1

Visceral adiposity index

DXA whole body scan visceral adiposity index

Time frame
DXA scan will be obtained on the same day as the oral glucose test and will be completed in less than 30 minutes
2

HOMA-IR

Insulin resistance estimate

Time frame
calculated from baseline fasting insulin and glucose levels
3

Disposition index

product of insulin sensitivity and amount of insulin released; calculated using mixed modeling techniques

Time frame
samples will be collected over four hours after the 75g glucose beverage and these results will be used for mixed modeling

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Pennsylvania

Lead sponsor

Source ClinicalTrials.gov
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